Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure

Angus K Nightingale; Daniel J Blackman; Rachel Field; Natalie J Glover; Nicholas Pegge; Catherine Mumford; Matthias Schmitt; Gethin R Ellis; Jayne A Morris-Thurgood; Michael P Frenneaux

doi:10.1042/CS20020334

Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure

Angus K Nightingale, Daniel J Blackman, Rachel Field, Natalie J Glover, Nicholas Pegge, Catherine Mumford, Matthias Schmitt, Gethin R Ellis, Jayne A Morris-Thurgood, Michael P Frenneaux

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Abnormalities of autonomic control of the cardiovascular system are seen in chronic heart failure (CHF) and confer a poor prognosis. Nitric oxide appears to be important in the regulation of baroreflex control in health and in disease states. The antioxidant vitamin C increases nitric oxide bioavailability in CHF. We evaluated the effects of vitamin C on baroreceptor sensitivity (BRS) by sequence analysis in 100 CHF patients and 44 control subjects. Groups of 55 CHF patients and 22 controls were randomly allocated to receive a single intravenous injection of vitamin C (2 g) or placebo. In addition, 45 CHF patients were randomly allocated to receive a 4-week course of oral vitamin C (4 g/day) or placebo. An age-related reference range for BRS was developed in 22 healthy controls matched for age and gender to the CHF group. BRS was significantly impaired in the CHF group compared with age-matched older controls and young controls (6.9 +/- 3.1, 12.5 +/- 4.9 and 21.7 +/- 9.1 mmHg/ms respectively; P

Original language	English
Pages (from-to)	529-35
Number of pages	7
Journal	Clinical Science
Volume	104
Issue number	5
DOIs	https://doi.org/10.1042/CS20020334
Publication status	Published - May 2003

Keywords

Administration, Oral
Adult
Aged
Ascorbic Acid
Baroreflex
Blood Flow Velocity
Case-Control Studies
Female
Heart Failure
Humans
Injections, Intravenous
Male
Middle Aged
Multivariate Analysis
Nitric Oxide
Oxidative Stress
Pressoreceptors

Access to Document

10.1042/CS20020334

Cite this

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title = "Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure",

abstract = "Abnormalities of autonomic control of the cardiovascular system are seen in chronic heart failure (CHF) and confer a poor prognosis. Nitric oxide appears to be important in the regulation of baroreflex control in health and in disease states. The antioxidant vitamin C increases nitric oxide bioavailability in CHF. We evaluated the effects of vitamin C on baroreceptor sensitivity (BRS) by sequence analysis in 100 CHF patients and 44 control subjects. Groups of 55 CHF patients and 22 controls were randomly allocated to receive a single intravenous injection of vitamin C (2 g) or placebo. In addition, 45 CHF patients were randomly allocated to receive a 4-week course of oral vitamin C (4 g/day) or placebo. An age-related reference range for BRS was developed in 22 healthy controls matched for age and gender to the CHF group. BRS was significantly impaired in the CHF group compared with age-matched older controls and young controls (6.9 +/- 3.1, 12.5 +/- 4.9 and 21.7 +/- 9.1 mmHg/ms respectively; P ",

keywords = "Administration, Oral, Adult, Aged, Ascorbic Acid, Baroreflex, Blood Flow Velocity, Case-Control Studies, Female, Heart Failure, Humans, Injections, Intravenous, Male, Middle Aged, Multivariate Analysis, Nitric Oxide, Oxidative Stress, Pressoreceptors",

author = "Nightingale, {Angus K} and Blackman, {Daniel J} and Rachel Field and Glover, {Natalie J} and Nicholas Pegge and Catherine Mumford and Matthias Schmitt and Ellis, {Gethin R} and Morris-Thurgood, {Jayne A} and Frenneaux, {Michael P}",

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AU - Pegge, Nicholas

AU - Mumford, Catherine

AU - Schmitt, Matthias

AU - Ellis, Gethin R

AU - Morris-Thurgood, Jayne A

AU - Frenneaux, Michael P

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N2 - Abnormalities of autonomic control of the cardiovascular system are seen in chronic heart failure (CHF) and confer a poor prognosis. Nitric oxide appears to be important in the regulation of baroreflex control in health and in disease states. The antioxidant vitamin C increases nitric oxide bioavailability in CHF. We evaluated the effects of vitamin C on baroreceptor sensitivity (BRS) by sequence analysis in 100 CHF patients and 44 control subjects. Groups of 55 CHF patients and 22 controls were randomly allocated to receive a single intravenous injection of vitamin C (2 g) or placebo. In addition, 45 CHF patients were randomly allocated to receive a 4-week course of oral vitamin C (4 g/day) or placebo. An age-related reference range for BRS was developed in 22 healthy controls matched for age and gender to the CHF group. BRS was significantly impaired in the CHF group compared with age-matched older controls and young controls (6.9 +/- 3.1, 12.5 +/- 4.9 and 21.7 +/- 9.1 mmHg/ms respectively; P

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