S phase of the cell cycle

Ronald A. Laskey, Micaela P. Fairman, J. Julian Blow

Research output: Contribution to journalSpecial issuepeer-review

Abstract

In each cell cycle the complex structure of the chromosome must be replicated accurately. In the last few years there have been major advances in understanding eukaryotic chromosome replication. Patterns of replication origins have been mapped accurately in yeast chromosomes. Cellular replication proteins have been identified by fractionating cell extracts that replicate viral DNA templates in vitro. Cell-free systems that initiate eukaryotic DNA replication in vitro have demonstrated the importance of complex nuclear architecture in the control of DNA replication. Although the events of S phase were relatively neglected for many years, knowledge of DNA replication is now advancing rapidly in step with other phases of the cell cycle.
Original languageEnglish
Pages (from-to)609-614
Number of pages6
JournalScience
Volume246
Issue number4930
DOIs
Publication statusPublished - 3 Nov 1989

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