Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes

Helen R Murphy; Kavita Kumareswaran; Daniela Elleri; Janet M Allen; Karen Caldwell; Martina Biagioni; David Simmons; David B Dunger; Marianna Nodale; Malgorzata E Wilinska; Stephanie A Amiel; Roman Hovorka

doi:10.2337/dc11-1430

Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes

Helen R Murphy, Kavita Kumareswaran, Daniela Elleri, Janet M Allen, Karen Caldwell, Martina Biagioni, David Simmons, David B Dunger, Marianna Nodale, Malgorzata E Wilinska, Stephanie A Amiel, Roman Hovorka

Research output: Contribution to journal › Article › peer-review

97 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII).

RESEARCH DESIGN AND METHODS: A total of 12 women with type 1 diabetes (aged 32.9 years, diabetes duration 17.6 years, BMI 27.1 kg/m(2), and HbA(1c) 6.4%) were randomly allocated to closed-loop or conventional CSII. They performed normal daily activities (standardized meals, snacks, and exercise) for 24 h on two occasions at 19 and 23 weeks' gestation. Plasma glucose time in target (63-140 mg/dL) and time spent hypoglycemic were calculated.

RESULTS: Plasma glucose time in target was comparable for closed-loop and conventional CSII (median [interquartile range]: 81 [59-87] vs. 81% [54-90]; P = 0.75). Less time was spent hypoglycemic (<45 mg/dL [0.0 vs. 0.3%]; P = 0.04), with a lower low blood glucose index (2.4 [0.9-3.5] vs. 3.3 [1.9-5.1]; P = 0.03), during closed-loop insulin delivery.

CONCLUSIONS: Closed-loop insulin delivery was as effective as conventional CSII, with less time spent in extreme hypoglycemia.

Original language	English
Pages (from-to)	2527-2529
Number of pages	3
Journal	Diabetes Care
Volume	34
Issue number	12
DOIs	https://doi.org/10.2337/dc11-1430
Publication status	Published - Dec 2011

Keywords

Adult
Blood Glucose
Cross-Over Studies
Type 1 Diabetes Mellitus
Female
Humans
Hypoglycemia
Insulin
Insulin Infusion Systems
Pregnancy
Pregnancy in Diabetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc11-1430

Cite this

@article{a4edc98d747b49359266b70aac928ea5,

title = "Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes",

abstract = "OBJECTIVE: To evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII).RESEARCH DESIGN AND METHODS: A total of 12 women with type 1 diabetes (aged 32.9 years, diabetes duration 17.6 years, BMI 27.1 kg/m(2), and HbA(1c) 6.4%) were randomly allocated to closed-loop or conventional CSII. They performed normal daily activities (standardized meals, snacks, and exercise) for 24 h on two occasions at 19 and 23 weeks' gestation. Plasma glucose time in target (63-140 mg/dL) and time spent hypoglycemic were calculated.RESULTS: Plasma glucose time in target was comparable for closed-loop and conventional CSII (median [interquartile range]: 81 [59-87] vs. 81% [54-90]; P = 0.75). Less time was spent hypoglycemic (<45 mg/dL [0.0 vs. 0.3%]; P = 0.04), with a lower low blood glucose index (2.4 [0.9-3.5] vs. 3.3 [1.9-5.1]; P = 0.03), during closed-loop insulin delivery.CONCLUSIONS: Closed-loop insulin delivery was as effective as conventional CSII, with less time spent in extreme hypoglycemia.",

keywords = "Adult, Blood Glucose, Cross-Over Studies, Type 1 Diabetes Mellitus, Female, Humans, Hypoglycemia, Insulin, Insulin Infusion Systems, Pregnancy, Pregnancy in Diabetics",

author = "Murphy, {Helen R} and Kavita Kumareswaran and Daniela Elleri and Allen, {Janet M} and Karen Caldwell and Martina Biagioni and David Simmons and Dunger, {David B} and Marianna Nodale and Wilinska, {Malgorzata E} and Amiel, {Stephanie A} and Roman Hovorka",

year = "2011",

month = dec,

doi = "10.2337/dc11-1430",

language = "English",

volume = "34",

pages = "2527--2529",

journal = "Diabetes Care",

issn = "0149-5992",

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TY - JOUR

T1 - Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes

AU - Murphy, Helen R

AU - Kumareswaran, Kavita

AU - Elleri, Daniela

AU - Allen, Janet M

AU - Caldwell, Karen

AU - Biagioni, Martina

AU - Simmons, David

AU - Dunger, David B

AU - Nodale, Marianna

AU - Wilinska, Malgorzata E

AU - Amiel, Stephanie A

AU - Hovorka, Roman

PY - 2011/12

Y1 - 2011/12

N2 - OBJECTIVE: To evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII).RESEARCH DESIGN AND METHODS: A total of 12 women with type 1 diabetes (aged 32.9 years, diabetes duration 17.6 years, BMI 27.1 kg/m(2), and HbA(1c) 6.4%) were randomly allocated to closed-loop or conventional CSII. They performed normal daily activities (standardized meals, snacks, and exercise) for 24 h on two occasions at 19 and 23 weeks' gestation. Plasma glucose time in target (63-140 mg/dL) and time spent hypoglycemic were calculated.RESULTS: Plasma glucose time in target was comparable for closed-loop and conventional CSII (median [interquartile range]: 81 [59-87] vs. 81% [54-90]; P = 0.75). Less time was spent hypoglycemic (<45 mg/dL [0.0 vs. 0.3%]; P = 0.04), with a lower low blood glucose index (2.4 [0.9-3.5] vs. 3.3 [1.9-5.1]; P = 0.03), during closed-loop insulin delivery.CONCLUSIONS: Closed-loop insulin delivery was as effective as conventional CSII, with less time spent in extreme hypoglycemia.

AB - OBJECTIVE: To evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII).RESEARCH DESIGN AND METHODS: A total of 12 women with type 1 diabetes (aged 32.9 years, diabetes duration 17.6 years, BMI 27.1 kg/m(2), and HbA(1c) 6.4%) were randomly allocated to closed-loop or conventional CSII. They performed normal daily activities (standardized meals, snacks, and exercise) for 24 h on two occasions at 19 and 23 weeks' gestation. Plasma glucose time in target (63-140 mg/dL) and time spent hypoglycemic were calculated.RESULTS: Plasma glucose time in target was comparable for closed-loop and conventional CSII (median [interquartile range]: 81 [59-87] vs. 81% [54-90]; P = 0.75). Less time was spent hypoglycemic (<45 mg/dL [0.0 vs. 0.3%]; P = 0.04), with a lower low blood glucose index (2.4 [0.9-3.5] vs. 3.3 [1.9-5.1]; P = 0.03), during closed-loop insulin delivery.CONCLUSIONS: Closed-loop insulin delivery was as effective as conventional CSII, with less time spent in extreme hypoglycemia.

KW - Adult

KW - Blood Glucose

KW - Cross-Over Studies

KW - Type 1 Diabetes Mellitus

KW - Female

KW - Humans

KW - Hypoglycemia

KW - Insulin

KW - Insulin Infusion Systems

KW - Pregnancy

KW - Pregnancy in Diabetics

U2 - 10.2337/dc11-1430

DO - 10.2337/dc11-1430

M3 - Article

C2 - 22011408

VL - 34

SP - 2527

EP - 2529

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 12

ER -