Safety of nonsteroidal anti-inflammatory drugs in major gastrointestinal surgery: A prospective, multicenter cohort study

STARSurg Collaborative

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Background: Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery.

Methods: Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals.

Results: From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560).

Conclusions: Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery.
Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalWorld Journal of Surgery
Volume41
Issue number1
Early online date20 Oct 2016
DOIs
Publication statusPublished - 2017

Cite this