Saturation transfer difference (STD) NMR spectroscopy characterization of dual binding mode of a mannose disaccharide to DC-SIGN

Jesus Angulo; Irene Díaz; Jose J. Reina; Georges Tabarani; Franck Fieschi; Javier Rojo; Pedro M. Nieto

doi:10.1002/cbic.200800361

Saturation transfer difference (STD) NMR spectroscopy characterization of dual binding mode of a mannose disaccharide to DC-SIGN

Jesus Angulo, Irene Díaz, Jose J. Reina, Georges Tabarani, Franck Fieschi, Javier Rojo, Pedro M. Nieto

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Concurrent multiple binding modes of a single ligand can be detected and quantified by saturation transfer difference (STD) NMR spectroscopy. Analysis of experimental and predicted STD initial growing rates has allowed us to determine the precise orientation of Man a(1?2)Man in the minor complex with the carbohydrate recognition domain of DC-SIGN.

Original language	English
Pages (from-to)	2225-2227
Number of pages	3
Journal	ChemBioChem
Volume	9
Issue number	14
DOIs	https://doi.org/10.1002/cbic.200800361
Publication status	Published - 22 Sep 2008

Keywords

DC-SIGN
mannose
molecualr recognition
NMR spectroscopy
STD-NMR

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10.1002/cbic.200800361

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AU - Tabarani, Georges

AU - Fieschi, Franck

AU - Rojo, Javier

AU - Nieto, Pedro M.

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KW - mannose

KW - molecualr recognition

KW - NMR spectroscopy

KW - STD-NMR

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Saturation transfer difference (STD) NMR spectroscopy characterization of dual binding mode of a mannose disaccharide to DC-SIGN

Abstract

Keywords

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