Saying a firm 'no' to DNA re-replication

J. Julian Blow, Tatyana A. Prokhorova

Research output: Contribution to journalComment/debatepeer-review

6 Citations (Scopus)


Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication ‘origins’ must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.
Original languageEnglish
Pages (from-to)E175-E177
Number of pages3
JournalNature Cell Biology
Issue number7
Publication statusPublished - Nov 1999

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