Saying a firm 'no' to DNA re-replication

J. Julian Blow; Tatyana A. Prokhorova

doi:10.1038/15611

Saying a firm 'no' to DNA re-replication

J. Julian Blow, Tatyana A. Prokhorova

Vice-Chancellor's Office

Research output: Contribution to journal › Comment/debate › peer-review

6 Citations (Scopus)

Abstract

Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication ‘origins’ must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.

Original language	English
Pages (from-to)	E175-E177
Number of pages	3
Journal	Nature Cell Biology
Volume	1
Issue number	7
DOIs	https://doi.org/10.1038/15611
Publication status	Published - Nov 1999

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10.1038/15611

Cite this

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title = "Saying a firm 'no' to DNA re-replication",

abstract = "Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication {\textquoteleft}origins{\textquoteright} must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.",

author = "Blow, {J. Julian} and Prokhorova, {Tatyana A.}",

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AU - Prokhorova, Tatyana A.

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AB - Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication ‘origins’ must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.

U2 - 10.1038/15611

DO - 10.1038/15611

M3 - Comment/debate

VL - 1

SP - E175-E177

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

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