Saying a firm 'no' to DNA re-replication

J. Julian Blow; Tatyana A. Prokhorova

doi:10.1038/15611

Saying a firm 'no' to DNA re-replication

J. Julian Blow
, Tatyana A. Prokhorova

Vice-Chancellor's Office

Research output: Contribution to journal › Comment/debate › peer-review

7 Citations (Scopus)

Abstract

Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication ‘origins’ must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.

Original language	English
Pages (from-to)	E175-E177
Number of pages	3
Journal	Nature Cell Biology
Volume	1
Issue number	7
DOIs	https://doi.org/10.1038/15611
Publication status	Published - Nov 1999

Access to Document

10.1038/15611

Cite this

@article{a060fa16cf3a46e8903a702a65e83a15,

title = "Saying a firm 'no' to DNA re-replication",

abstract = "Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication {\textquoteleft}origins{\textquoteright} must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.",

author = "Blow, \{J. Julian\} and Prokhorova, \{Tatyana A.\}",

year = "1999",

month = nov,

doi = "10.1038/15611",

language = "English",

volume = "1",

pages = "E175--E177",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Research",

number = "7",

}

TY - JOUR

T1 - Saying a firm 'no' to DNA re-replication

AU - Blow, J. Julian

AU - Prokhorova, Tatyana A.

PY - 1999/11

Y1 - 1999/11

N2 - Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication ‘origins’ must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.

AB - Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication ‘origins’ must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.

U2 - 10.1038/15611

DO - 10.1038/15611

M3 - Comment/debate

SN - 1465-7392

VL - 1

SP - E175-E177

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 7

ER -