Projects per year
Abstract
Background: About 14.9% of people (9.9 million) registered with primary care practices in England and Wales are prescribed medication for hypertension. However, many do not take their medication as prescribed. To address this
problem, we need scalable interventions.
Objective: To develop a scalable low-cost intervention to support medication adherence in people prescribed medication for hypertension in primary care, and to obtain precise and robust estimates of the effectiveness and cost
effectiveness of the intervention compared with usual care.
Design: Systematic reviews and meta-analyses; qualitative meta-synthesis; interviews and focus groups; expert consultations; pre-testing study; randomised feasibility trial; randomised controlled trial of effectiveness and cost
effectiveness; economic modelling.
Setting and participants: Primary care practices in England and Wales. Patients prescribed medication for hypertension with poorly controlled blood pressure.
Interventions: Very brief intervention delivered by a practice nurse or healthcare assistant followed by a digital intervention (text messaging programme or smartphone app).
Main outcome measures: Acceptability, feasibility, fidelity and cost of the interventions. Systolic blood pressure. Biochemical and self-reported measures of medication adherence.
Results: Our systematic reviews showed that both app-based and face-to-face interventions in patients with long-term conditions have a positive effect on medication adherence.
problem, we need scalable interventions.
Objective: To develop a scalable low-cost intervention to support medication adherence in people prescribed medication for hypertension in primary care, and to obtain precise and robust estimates of the effectiveness and cost
effectiveness of the intervention compared with usual care.
Design: Systematic reviews and meta-analyses; qualitative meta-synthesis; interviews and focus groups; expert consultations; pre-testing study; randomised feasibility trial; randomised controlled trial of effectiveness and cost
effectiveness; economic modelling.
Setting and participants: Primary care practices in England and Wales. Patients prescribed medication for hypertension with poorly controlled blood pressure.
Interventions: Very brief intervention delivered by a practice nurse or healthcare assistant followed by a digital intervention (text messaging programme or smartphone app).
Main outcome measures: Acceptability, feasibility, fidelity and cost of the interventions. Systolic blood pressure. Biochemical and self-reported measures of medication adherence.
Results: Our systematic reviews showed that both app-based and face-to-face interventions in patients with long-term conditions have a positive effect on medication adherence.
| Original language | English |
|---|---|
| Pages (from-to) | 1-46 |
| Journal | Programme Grants for Applied Research |
| Volume | 14 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 6 Aug 2026 |
Projects
- 1 Finished
-
Scalable low-cost interventions to support medication adherence in people prescribed treatment for hypertension in primary care
Hardeman, W. (Principal Investigator), Sutton, S. (Principal Investigator), Bhattacharya, D. (Co-Investigator), Brimicombe, D. (Co-Investigator), Eborall, H. (Co-Investigator), Griffin, S. (Co-Investigator), Hardeman, W. (Co-Investigator), Mant, J. (Co-Investigator), Mascolo, C. (Co-Investigator), McManus, R. (Co-Investigator), Naughton, F. (Co-Investigator), Naughton, F. (Co-Investigator), Prevost, A. (Co-Investigator), Prevost, T. (Co-Investigator), Simoni, A. (Co-Investigator), Takhar, A. (Co-Investigator) & Wilson, E. (Co-Investigator)
National Institute for Health and Care Research
1/06/17 → 31/05/24
Project: Research
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