Abstract
Trans-disubstituted porphyrins are highly valuable intermediates across diverse fields, but they pose a significant synthesis challenge in some cases due to scrambling and formation of complex mixtures. Conditions that minimize scrambling also lower yields, but steric hindrance around the meso-aryl substituent can effectively suppress scrambling altogether. Here we report a straightforward approach to valuable trans-A2B2 porphyrin intermediates that are otherwise very difficult to obtain, through use of removable blocking bromide substituents.
Original language | English |
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Pages (from-to) | 1561-1565 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 26 |
Issue number | 8 |
Early online date | 19 Feb 2024 |
DOIs | |
Publication status | Published - 1 Mar 2024 |