Seasonal variation in 25(OH)D at Aberdeen (57°N) and bone health indicators- Could holidays in the sun and cod liver oil supplements alleviate deficiency?

Alexandra Mavroeidi, Lorna Aucott, Alison J. Black, William D. Fraser, David M. Reid, Helen M. Macdonald

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Vitamin D has been linked with many health outcomes. The aim of this longitudinal study, was to assess predictors of seasonal variation of 25-hydroxy-vitamin D (25(OH)D) (including use of supplements and holidays in sunny destinations) at a northerly latitude in the UK (57°N) in relation to bone health indicators. 365 healthy postmenopausal women (mean age 62.0 y (SD 1.4)) had 25(OH)D measurements by immunoassay, serum C-telopeptide (CTX), estimates of sunlight exposure (badges of polysulphone film), information regarding holidays in sunny destinations, and diet (from food diaries, including use of supplements such as cod liver oil (CLO)) at fixed 3-monthly intervals over 15 months (subject retention 88%) with an additional 25(OH)D assessment in spring 2008. Bone mineral density (BMD) at the lumbar spine (LS) and dual hip was measured in autumn 2006 and spring 2007 (Lunar I-DXA). Deficiency prevalence (25(OH)D
Original languageEnglish
Article numbere53381
JournalPLoS One
Issue number1
Publication statusPublished - 8 Jan 2013


  • Absorptiometry, Photon
  • Bone Density
  • Bone and Bones
  • Cod Liver Oil
  • Collagen Type I
  • Dietary Supplements
  • Female
  • Great Britain
  • Hip
  • Holidays
  • Humans
  • Longitudinal Studies
  • Lumbosacral Region
  • Middle Aged
  • Parathyroid Hormone
  • Peptides
  • Postmenopause
  • Seasons
  • Sunlight
  • Vitamin D
  • Vitamin D Deficiency

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