Additions of paracetamol using cyclic voltammetry exhibits a linear detection range over a wide range of paracetamol concentrations (0.1–25 µM) with a detection limit of 45 nM (based on 3s). Additions of paracetamol using square wave adsorptive stripping voltammetry show two linear ranges for paracetamol detection. The first linear range is from 0.01 µM to 2 µM and the second linear range is from 2 µM to 20 µM. Using the first range of this calibration plot, a detection limit of 10 nM is obtained for paracetamol. To the best of our knowledge, this limit of detection is the lowest limit of detection has been reported for paracetamol using electrochemical techniques.
The method was then successfully utilised for the determination of paracetamol in a real sample of “ANADIN EXTRA” tablets and a recovery of 95% was obtained without interference from aspirin or caffeine. The proposed electroanalytical method using MWCNT-BPPGE is the most sensitive method for determination of paracetamol with lowest limit of detection to date. It has also advantages such as easy handling, resistance against surface fouling, and low cost.