Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes; Jeffrey C Barrett; Natalie J Prescott; Mark Tremelling; Carl A Anderson; Sheila A Fisher; Roland G Roberts; Elaine R Nimmo; Fraser R Cummings; Dianne Soars; Hazel Drummond; Charlie W Lees; Saud A Khawaja; Richard Bagnall; Denis A Burke; Catherine E Todhunter; Tariq Ahmad; Clive M Onnie; Wendy McArdle; David Strachan; Graeme Bethel; Claire Bryan; Cathryn M Lewis; Panos Deloukas; Alastair Forbes; Jeremy Sanderson; Derek P Jewell; Jack Satsangi; John C Mansfield; Lon Cardon; Christopher G Mathew; Wellcome Trust Case Control Consortium

doi:10.1038/ng2061

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars, Hazel Drummond, Charlie W Lees, Saud A Khawaja, Richard Bagnall, Denis A Burke, Catherine E Todhunter, Tariq Ahmad, Clive M Onnie, Wendy McArdle, David StrachanGraeme Bethel, Claire Bryan, Cathryn M Lewis, Panos Deloukas, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, Jack Satsangi, John C Mansfield, Lon Cardon, Christopher G Mathew, Wellcome Trust Case Control Consortium

Research output: Contribution to journal › Article › peer-review

1004 Citations (Scopus)

Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

Original language	English
Pages (from-to)	830-2
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	7
DOIs	https://doi.org/10.1038/ng2061
Publication status	Published - Jul 2007

Keywords

Animals
Autophagy
Case-Control Studies
Crohn Disease
GTP-Binding Proteins
Genetic Predisposition to Disease
Genetic Variation
Humans
Mice
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

Access to Document

10.1038/ng2061

Cite this

Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. R., Soars, D., Drummond, H., Lees, C. W., Khawaja, S. A., Bagnall, R., Burke, D. A., Todhunter, C. E., Ahmad, T., Onnie, C. M., McArdle, W., ... Wellcome Trust Case Control Consortium (2007). Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genetics, 39(7), 830-2. https://doi.org/10.1038/ng2061

Parkes, Miles ; Barrett, Jeffrey C ; Prescott, Natalie J ; Tremelling, Mark ; Anderson, Carl A ; Fisher, Sheila A ; Roberts, Roland G ; Nimmo, Elaine R ; Cummings, Fraser R ; Soars, Dianne ; Drummond, Hazel ; Lees, Charlie W ; Khawaja, Saud A ; Bagnall, Richard ; Burke, Denis A ; Todhunter, Catherine E ; Ahmad, Tariq ; Onnie, Clive M ; McArdle, Wendy ; Strachan, David ; Bethel, Graeme ; Bryan, Claire ; Lewis, Cathryn M ; Deloukas, Panos ; Forbes, Alastair ; Sanderson, Jeremy ; Jewell, Derek P ; Satsangi, Jack ; Mansfield, John C ; Cardon, Lon ; Mathew, Christopher G ; Wellcome Trust Case Control Consortium. / Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. In: Nature Genetics. 2007 ; Vol. 39, No. 7. pp. 830-2.

@article{b7031c0f85054b78ac1065f57166989b,

title = "Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility",

abstract = "A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.",

keywords = "Animals, Autophagy, Case-Control Studies, Crohn Disease, GTP-Binding Proteins, Genetic Predisposition to Disease, Genetic Variation, Humans, Mice, Polymorphism, Single Nucleotide, Sequence Analysis, DNA",

author = "Miles Parkes and Barrett, {Jeffrey C} and Prescott, {Natalie J} and Mark Tremelling and Anderson, {Carl A} and Fisher, {Sheila A} and Roberts, {Roland G} and Nimmo, {Elaine R} and Cummings, {Fraser R} and Dianne Soars and Hazel Drummond and Lees, {Charlie W} and Khawaja, {Saud A} and Richard Bagnall and Burke, {Denis A} and Todhunter, {Catherine E} and Tariq Ahmad and Onnie, {Clive M} and Wendy McArdle and David Strachan and Graeme Bethel and Claire Bryan and Lewis, {Cathryn M} and Panos Deloukas and Alastair Forbes and Jeremy Sanderson and Jewell, {Derek P} and Jack Satsangi and Mansfield, {John C} and Lon Cardon and Mathew, {Christopher G} and {Wellcome Trust Case Control Consortium}",

year = "2007",

month = jul,

doi = "10.1038/ng2061",

language = "English",

volume = "39",

pages = "830--2",

journal = "Nature Genetics",

issn = "1061-4036",

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Parkes, M, Barrett, JC, Prescott, NJ, Tremelling, M, Anderson, CA, Fisher, SA, Roberts, RG, Nimmo, ER, Cummings, FR, Soars, D, Drummond, H, Lees, CW, Khawaja, SA, Bagnall, R, Burke, DA, Todhunter, CE, Ahmad, T, Onnie, CM, McArdle, W, Strachan, D, Bethel, G, Bryan, C, Lewis, CM, Deloukas, P, Forbes, A, Sanderson, J, Jewell, DP, Satsangi, J, Mansfield, JC, Cardon, L, Mathew, CG & Wellcome Trust Case Control Consortium 2007, 'Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility', Nature Genetics, vol. 39, no. 7, pp. 830-2. https://doi.org/10.1038/ng2061

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. / Parkes, Miles; Barrett, Jeffrey C; Prescott, Natalie J; Tremelling, Mark; Anderson, Carl A; Fisher, Sheila A; Roberts, Roland G; Nimmo, Elaine R; Cummings, Fraser R; Soars, Dianne; Drummond, Hazel; Lees, Charlie W; Khawaja, Saud A; Bagnall, Richard; Burke, Denis A; Todhunter, Catherine E; Ahmad, Tariq; Onnie, Clive M; McArdle, Wendy; Strachan, David; Bethel, Graeme; Bryan, Claire; Lewis, Cathryn M; Deloukas, Panos; Forbes, Alastair; Sanderson, Jeremy; Jewell, Derek P; Satsangi, Jack; Mansfield, John C; Cardon, Lon; Mathew, Christopher G; Wellcome Trust Case Control Consortium.

In: Nature Genetics, Vol. 39, No. 7, 07.2007, p. 830-2.

Research output: Contribution to journal › Article › peer-review

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AU - Prescott, Natalie J

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AU - Fisher, Sheila A

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AU - Nimmo, Elaine R

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AU - Soars, Dianne

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AU - Lees, Charlie W

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AU - Burke, Denis A

AU - Todhunter, Catherine E

AU - Ahmad, Tariq

AU - Onnie, Clive M

AU - McArdle, Wendy

AU - Strachan, David

AU - Bethel, Graeme

AU - Bryan, Claire

AU - Lewis, Cathryn M

AU - Deloukas, Panos

AU - Forbes, Alastair

AU - Sanderson, Jeremy

AU - Jewell, Derek P

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AU - Mathew, Christopher G

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KW - Animals

KW - Autophagy

KW - Case-Control Studies

KW - Crohn Disease

KW - GTP-Binding Proteins

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Humans

KW - Mice

KW - Polymorphism, Single Nucleotide

KW - Sequence Analysis, DNA

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JO - Nature Genetics

JF - Nature Genetics

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