Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars, Hazel Drummond, Charlie W Lees, Saud A Khawaja, Richard Bagnall, Denis A Burke, Catherine E Todhunter, Tariq Ahmad, Clive M Onnie, Wendy McArdle, David StrachanGraeme Bethel, Claire Bryan, Cathryn M Lewis, Panos Deloukas, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, Jack Satsangi, John C Mansfield, Lon Cardon, Christopher G Mathew, Wellcome Trust Case Control Consortium

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Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
Original languageEnglish
Pages (from-to)830-2
Number of pages3
JournalNature Genetics
Volume39
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Animals
  • Autophagy
  • Case-Control Studies
  • Crohn Disease
  • GTP-Binding Proteins
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Humans
  • Mice
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA

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