Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ

Joseph A. Wright, Jiangang Yu, Jonathan B. Spencer

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The selective cleavage of the PMB (4-methoxybenzyl) group in the presence of the NAP (2-naphthylmethyl) group was achieved using CAN with a range of mono-saccharides. The NAP group can then be removed selectively in the presence of a benzyl group using DDQ. This provides a strategy for sequential deprotection of hydroxyl groups.
Original languageEnglish
Pages (from-to)4033-4036
Number of pages4
JournalTetrahedron Letters
Issue number24
Publication statusPublished - 2001

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