Serological markers predict inflammatory bowel disease years before the diagnosis

Fiona D M van Schaik, Bas Oldenburg, Andrew R Hart, Peter D Siersema, Stefan Lindgren, Olof Grip, Birgit Teucher, Rudolf Kaaks, Manuela M Bergmann, Heiner Boeing, Franck Carbonnel, Prevost Jantchou, Marie-Christine Boutron-Ruault, Anne Tjønneland, Anja Olsen, Francesca L Crowe, Petra H M Peeters, Martijn G H van Oijen, H Bas Bueno-de-Mesquita

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD.
Original languageEnglish
Pages (from-to)683-8
Number of pages6
JournalGut
Volume62
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic
  • Biological Markers
  • Case-Control Studies
  • Cohort Studies
  • Colitis, Ulcerative
  • Crohn Disease
  • Europe
  • Female
  • Flagellin
  • Follow-Up Studies
  • Humans
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunologic Factors
  • Inflammatory Bowel Diseases
  • Logistic Models
  • Male
  • Middle Aged
  • Porins
  • Predictive Value of Tests
  • Prospective Studies
  • Sensitivity and Specificity

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