Serological markers predict inflammatory bowel disease years before the diagnosis

Fiona D M van Schaik; Bas Oldenburg; Andrew R Hart; Peter D Siersema; Stefan Lindgren; Olof Grip; Birgit Teucher; Rudolf Kaaks; Manuela M Bergmann; Heiner Boeing; Franck Carbonnel; Prevost Jantchou; Marie-Christine Boutron-Ruault; Anne Tjønneland; Anja Olsen; Francesca L Crowe; Petra H M Peeters; Martijn G H van Oijen; H Bas Bueno-de-Mesquita

doi:10.1136/gutjnl-2012-302717

Serological markers predict inflammatory bowel disease years before the diagnosis

Fiona D M van Schaik, Bas Oldenburg, Andrew R Hart, Peter D Siersema, Stefan Lindgren, Olof Grip, Birgit Teucher, Rudolf Kaaks, Manuela M Bergmann, Heiner Boeing, Franck Carbonnel, Prevost Jantchou, Marie-Christine Boutron-Ruault, Anne Tjønneland, Anja Olsen, Francesca L Crowe, Petra H M Peeters, Martijn G H van Oijen, H Bas Bueno-de-Mesquita

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD.

Original language	English
Pages (from-to)	683-8
Number of pages	6
Journal	Gut
Volume	62
Issue number	5
DOIs	https://doi.org/10.1136/gutjnl-2012-302717
Publication status	Published - May 2013

Keywords

Adult
Antibodies, Antineutrophil Cytoplasmic
Biological Markers
Case-Control Studies
Cohort Studies
Colitis, Ulcerative
Crohn Disease
Europe
Female
Flagellin
Follow-Up Studies
Humans
Immunoglobulin A
Immunoglobulin G
Immunologic Factors
Inflammatory Bowel Diseases
Logistic Models
Male
Middle Aged
Porins
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity

Access to Document

10.1136/gutjnl-2012-302717

Cite this

van Schaik, F. D. M., Oldenburg, B., Hart, A. R., Siersema, P. D., Lindgren, S., Grip, O., Teucher, B., Kaaks, R., Bergmann, M. M., Boeing, H., Carbonnel, F., Jantchou, P., Boutron-Ruault, M-C., Tjønneland, A., Olsen, A., Crowe, F. L., Peeters, P. H. M., van Oijen, M. G. H., & Bueno-de-Mesquita, H. B. (2013). Serological markers predict inflammatory bowel disease years before the diagnosis. Gut, 62(5), 683-8. https://doi.org/10.1136/gutjnl-2012-302717

@article{82b8d43d936948edbd02518872c40454,

title = "Serological markers predict inflammatory bowel disease years before the diagnosis",

abstract = "Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD.",

keywords = "Adult, Antibodies, Antineutrophil Cytoplasmic, Biological Markers, Case-Control Studies, Cohort Studies, Colitis, Ulcerative, Crohn Disease, Europe, Female, Flagellin, Follow-Up Studies, Humans, Immunoglobulin A, Immunoglobulin G, Immunologic Factors, Inflammatory Bowel Diseases, Logistic Models, Male, Middle Aged, Porins, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity",

author = "{van Schaik}, {Fiona D M} and Bas Oldenburg and Hart, {Andrew R} and Siersema, {Peter D} and Stefan Lindgren and Olof Grip and Birgit Teucher and Rudolf Kaaks and Bergmann, {Manuela M} and Heiner Boeing and Franck Carbonnel and Prevost Jantchou and Marie-Christine Boutron-Ruault and Anne Tj{\o}nneland and Anja Olsen and Crowe, {Francesca L} and Peeters, {Petra H M} and {van Oijen}, {Martijn G H} and Bueno-de-Mesquita, {H Bas}",

year = "2013",

month = may,

doi = "10.1136/gutjnl-2012-302717",

language = "English",

volume = "62",

pages = "683--8",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ Publishing Group",

number = "5",

}

van Schaik, FDM, Oldenburg, B, Hart, AR, Siersema, PD, Lindgren, S, Grip, O, Teucher, B, Kaaks, R, Bergmann, MM, Boeing, H, Carbonnel, F, Jantchou, P, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Crowe, FL, Peeters, PHM, van Oijen, MGH & Bueno-de-Mesquita, HB 2013, 'Serological markers predict inflammatory bowel disease years before the diagnosis', Gut, vol. 62, no. 5, pp. 683-8. https://doi.org/10.1136/gutjnl-2012-302717

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T1 - Serological markers predict inflammatory bowel disease years before the diagnosis

AU - van Schaik, Fiona D M

AU - Oldenburg, Bas

AU - Hart, Andrew R

AU - Siersema, Peter D

AU - Lindgren, Stefan

AU - Grip, Olof

AU - Teucher, Birgit

AU - Kaaks, Rudolf

AU - Bergmann, Manuela M

AU - Boeing, Heiner

AU - Carbonnel, Franck

AU - Jantchou, Prevost

AU - Boutron-Ruault, Marie-Christine

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Crowe, Francesca L

AU - Peeters, Petra H M

AU - van Oijen, Martijn G H

AU - Bueno-de-Mesquita, H Bas

PY - 2013/5

Y1 - 2013/5

N2 - Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD.

AB - Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD.

KW - Adult

KW - Antibodies, Antineutrophil Cytoplasmic

KW - Biological Markers

KW - Case-Control Studies

KW - Cohort Studies

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Europe

KW - Female

KW - Flagellin

KW - Follow-Up Studies

KW - Humans

KW - Immunoglobulin A

KW - Immunoglobulin G

KW - Immunologic Factors

KW - Inflammatory Bowel Diseases

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Porins

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Sensitivity and Specificity

U2 - 10.1136/gutjnl-2012-302717

DO - 10.1136/gutjnl-2012-302717

M3 - Article

C2 - 22842615

VL - 62

SP - 683

EP - 688

JO - Gut

JF - Gut

SN - 0017-5749

IS - 5

ER -