SERRATE: a new player on the plant microRNA scene

Dajana Lobbes; Ghanasyam Rallapalli; Dominik D Schmidt; Cathie Martin; Jonathan Clarke

doi:10.1038/sj.embor.7400806

SERRATE: a new player on the plant microRNA scene

Dajana Lobbes, Ghanasyam Rallapalli, Dominik D Schmidt, Cathie Martin, Jonathan Clarke

Research output: Contribution to journal › Article › peer-review

300 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of mutants defective in miRNA accumulation. Although it has been proposed that SERRATE (SE) functions specifically in miRNA-mediated repression of the leaf polarity genes PHABULOSA and PHAVOLUTA, microarray analysis shows upregulation of many genes known to be the targets of miRNAs in se-1. We show that SE is a general regulator of miRNA levels affecting the processing of primary miRNA to miRNA.

Original language	English
Pages (from-to)	1052-1058
Number of pages	7
Journal	EMBO Reports
Volume	7
Issue number	10
DOIs	https://doi.org/10.1038/sj.embor.7400806
Publication status	Published - Oct 2006

Keywords

Alleles
Arabidopsis
Arabidopsis Proteins
Calcium-Binding Proteins
Gene Expression Regulation, Plant
Genes, Plant
Intercellular Signaling Peptides and Proteins
Membrane Proteins
MicroRNAs
Phenotype
Plants, Genetically Modified
Protein Binding
RNA Stability
RNA, Plant
RNA-Binding Proteins
Seeds

Access to Document

10.1038/sj.embor.7400806

Cite this

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title = "SERRATE: a new player on the plant microRNA scene",

abstract = "MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of mutants defective in miRNA accumulation. Although it has been proposed that SERRATE (SE) functions specifically in miRNA-mediated repression of the leaf polarity genes PHABULOSA and PHAVOLUTA, microarray analysis shows upregulation of many genes known to be the targets of miRNAs in se-1. We show that SE is a general regulator of miRNA levels affecting the processing of primary miRNA to miRNA.",

keywords = "Alleles, Arabidopsis, Arabidopsis Proteins, Calcium-Binding Proteins, Gene Expression Regulation, Plant, Genes, Plant, Intercellular Signaling Peptides and Proteins, Membrane Proteins, MicroRNAs, Phenotype, Plants, Genetically Modified, Protein Binding, RNA Stability, RNA, Plant, RNA-Binding Proteins, Seeds",

author = "Dajana Lobbes and Ghanasyam Rallapalli and Schmidt, {Dominik D} and Cathie Martin and Jonathan Clarke",

year = "2006",

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language = "English",

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T1 - SERRATE: a new player on the plant microRNA scene

AU - Lobbes, Dajana

AU - Rallapalli, Ghanasyam

AU - Schmidt, Dominik D

AU - Martin, Cathie

AU - Clarke, Jonathan

PY - 2006/10

Y1 - 2006/10

N2 - MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of mutants defective in miRNA accumulation. Although it has been proposed that SERRATE (SE) functions specifically in miRNA-mediated repression of the leaf polarity genes PHABULOSA and PHAVOLUTA, microarray analysis shows upregulation of many genes known to be the targets of miRNAs in se-1. We show that SE is a general regulator of miRNA levels affecting the processing of primary miRNA to miRNA.

AB - MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of mutants defective in miRNA accumulation. Although it has been proposed that SERRATE (SE) functions specifically in miRNA-mediated repression of the leaf polarity genes PHABULOSA and PHAVOLUTA, microarray analysis shows upregulation of many genes known to be the targets of miRNAs in se-1. We show that SE is a general regulator of miRNA levels affecting the processing of primary miRNA to miRNA.

KW - Alleles

KW - Arabidopsis

KW - Arabidopsis Proteins

KW - Calcium-Binding Proteins

KW - Gene Expression Regulation, Plant

KW - Genes, Plant

KW - Intercellular Signaling Peptides and Proteins

KW - Membrane Proteins

KW - MicroRNAs

KW - Phenotype

KW - Plants, Genetically Modified

KW - Protein Binding

KW - RNA Stability

KW - RNA, Plant

KW - RNA-Binding Proteins

KW - Seeds

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DO - 10.1038/sj.embor.7400806

M3 - Article

C2 - 16977334

VL - 7

SP - 1052

EP - 1058

JO - EMBO Reports

JF - EMBO Reports

SN - 1469-221X

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ER -