Sesquiterpenoids with anti-MDR Staphylococcus aureus activities from Ferula ferulioides

Tao Liu; Shuangying Wang; Lili Xu; Wei Fu; Simon Gibbons; Qing Mu

doi:10.1002/cbdv.201400150

Sesquiterpenoids with anti-MDR Staphylococcus aureus activities from Ferula ferulioides

Tao Liu, Shuangying Wang, Lili Xu, Wei Fu, Simon Gibbons, Qing Mu

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides (Steud.) Korovin. Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration (MIC) values in the range of 0.5-128 mg/l.

Original language	English
Pages (from-to)	599-614
Number of pages	16
Journal	Chemistry and Biodiversity
Volume	12
Issue number	4
Early online date	16 Apr 2015
DOIs	https://doi.org/10.1002/cbdv.201400150
Publication status	Published - Apr 2015

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10.1002/cbdv.201400150

Cite this

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title = "Sesquiterpenoids with anti-MDR Staphylococcus aureus activities from Ferula ferulioides",

abstract = "Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides (Steud.) Korovin. Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration (MIC) values in the range of 0.5-128 mg/l.",

author = "Tao Liu and Shuangying Wang and Lili Xu and Wei Fu and Simon Gibbons and Qing Mu",

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AU - Liu, Tao

AU - Wang, Shuangying

AU - Xu, Lili

AU - Fu, Wei

AU - Gibbons, Simon

AU - Mu, Qing

PY - 2015/4

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AB - Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides (Steud.) Korovin. Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration (MIC) values in the range of 0.5-128 mg/l.

U2 - 10.1002/cbdv.201400150

DO - 10.1002/cbdv.201400150

M3 - Article

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SP - 599

EP - 614

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

SN - 1612-1872

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