Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis

Matthew Rutter, Brian Saunders, Kay Wilkinson, Steve Rumbles, Gillian Schofield, Michael Kamm, Christopher Williams, Ashley Price, Ian Talbot, Alastair Forbes

Research output: Contribution to journalArticle

920 Citations (Scopus)

Abstract

Patients with ulcerative colitis are at increased risk of colorectal cancer. It is widely believed that this is secondary to colonic inflammation. However, the severity of colonic inflammation has never been shown to be a risk factor.
Original languageEnglish
Pages (from-to)451-9
Number of pages9
JournalGastroenterology
Volume126
Issue number2
Publication statusPublished - Feb 2004

Keywords

  • Adolescent
  • Adult
  • Case-Control Studies
  • Child
  • Colitis, Ulcerative
  • Colonoscopy
  • Colorectal Neoplasms
  • Cytoprotection
  • Female
  • Humans
  • Male
  • Mesalamine
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Risk Factors
  • Severity of Illness Index
  • Smoking
  • Sulfasalazine

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