Shape and Polarity in Co-crystal Formation: Database Analysis and Experimental Validation

L. Fabian, T. Frišcic

Research output: Chapter in Book/Report/Conference proceedingChapter


Supramolecular synthons provide the most important and successful approach to the rational design of co-crystals. Yet, the relatively low success rate of co-crystal screening experiments demonstrates that the availability of appropriate synthons is only one of many factors that influence co-crystallisation. The aim of our work was to identify other factors and to use them in developing design strategies that are complementary to supramolecular synthons.
Original languageEnglish
Title of host publicationPharmaceutical Salts and Co-crystals
PublisherRoyal Society of Chemistry
Number of pages21
ISBN (Print)978-1-84973-158-4
Publication statusPublished - 2012

Publication series

NameRSC Drug Discovery Series
PublisherRoyal Society of Chemistry

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