Shiga toxin binding in normal and inflamed human intestinal mucosa

Stephanie Schuller; Robert Heuschkel; Franco Torrente; James B. Kaper; Alan D. Phillips

doi:10.1016/j.micinf.2006.10.005

Shiga toxin binding in normal and inflamed human intestinal mucosa

Stephanie Schuller, Robert Heuschkel, Franco Torrente, James B. Kaper, Alan D. Phillips

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51 Citations (Scopus)

Abstract

Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Microbes and Infection
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/j.micinf.2006.10.005
Publication status	Published - Jan 2007

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10.1016/j.micinf.2006.10.005

Cite this

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title = "Shiga toxin binding in normal and inflamed human intestinal mucosa",

abstract = "Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.",

author = "Stephanie Schuller and Robert Heuschkel and Franco Torrente and Kaper, {James B.} and Phillips, {Alan D.}",

year = "2007",

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T1 - Shiga toxin binding in normal and inflamed human intestinal mucosa

AU - Schuller, Stephanie

AU - Heuschkel, Robert

AU - Torrente, Franco

AU - Kaper, James B.

AU - Phillips, Alan D.

PY - 2007/1

Y1 - 2007/1

N2 - Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.

AB - Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.

U2 - 10.1016/j.micinf.2006.10.005

DO - 10.1016/j.micinf.2006.10.005

M3 - Article

VL - 9

SP - 35

EP - 39

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 1

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