@article{7d161e6645a84389ab653ab0537680ea,
title = "Short-cut bio-inspired synthesis of tricyclic guanidinic motifs of crambescidins and batzelladines marine alkaloids",
abstract = "We report a convenient short synthesis of tricyclic guanidine-containing natural products model featuring four-component reaction between 2,5-dimethoxytetrahydrofuran, 2-aminopyrimidine and two acylacetic or benzoylacetic acids. A synthetic route combining the Robinson–Sch{\"o}epf bioinspired strategy and biomechanistic analysis of the crambescidin and batzelladine alkaloids family. An application of this strategy to the synthesis of two unnatural stereoisomers of merobatzelladine B is described from the protected guanidine in the form of aminopyrimidine.",
keywords = "Batzelladines, Bioactivity, Crambescidins, Guanidine alkaloids, Multicomponent reactions",
author = "Amr El-Demerdash and Ludmila Ermolenko and Emmanuelle Gros and Pascal Retailleau and Thanh, {Binh Nguyen} and Anne Gauvin-Bialecki and Ali Al-Mourabit",
note = "Funding Information: Financial support from CNRS is gratefully acknowledged. The authors thank the ANR (POMARE project, 2011‐EBIM‐006‐01). A. El‐Demerdash's PhD was granted and financed by the Egyptian Government (Ministry of Higher Education), they are gratefully acknowledged. Special thanks for J‐F. Gallard for technical assistance and NMR measurements. Remerciement Robert Dodd Funding Information: Financial support from CNRS is gratefully acknowledged. The authors thank the ANR (POMARE project, 2011-EBIM-006-01). A. El-Demerdash's PhD was granted and financed by the Egyptian Government (Ministry of Higher Education), they are gratefully acknowledged. Special thanks for J-F. Gallard for technical assistance and NMR measurements. Remerciement Robert Dodd Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = sep,
day = "22",
doi = "10.1002/ejoc.202000744",
language = "English",
volume = "2020",
pages = "5677--5684",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
publisher = "Wiley",
number = "35",
}
