Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury

Laura Miles, Robert I. Grossman, Glyn Johnson, James S. Babb, Leonard Diller, Matilde Inglese

Research output: Contribution to journalArticlepeer-review

203 Citations (Scopus)


PRIMARY OBJECTIVE: To explore whether baseline diffusion tensor imaging (DTI) metrics are predictive of cognitive functioning 6 months post-injury in patients with mild traumatic brain injury (MTBI). RESEARCH DESIGN: Seventeen patients with MTBI and 29 sex- and age-matched healthy controls were studied. METHODS AND PROCEDURES: Participants underwent an MRI protocol including DTI, at an average of 4.0 (range: 1-10) days post-injury. Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the following white matter (WM) regions: centra semiovale, the genu and the splenium of the corpus callosum and the posterior limb of the internal capsule. Participants underwent neuropsychological (NP) testing at baseline and at 6-month follow-up. Least squares regression analysis was used to evaluate the association of MD and FA with each NP test score at baseline and follow-up. MAIN OUTCOMES AND RESULTS: Compared to controls, average MD was significantly higher (p = 0.02) and average FA significantly lower (p = 0.0001) in MTBI patients. At the follow-up, there was a trend toward a significant association between baseline MD and response speed (r = -0.53, p = 0.087) and a positive correlation between baseline FA and Prioritization form B (r = 0.72, p = 0.003). CONCLUSIONS: DTI may provide short-term non-invasive predictive markers of cognitive functioning in patients with MTBI.
Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalBrain Injury
Issue number2
Publication statusPublished - 2008


  • Adolescent Adult Brain/pathology Brain Injuries/*complications Case-Control Studies Cognition Disorders/*diagnosis Diffusion Magnetic Resonance Imaging/*methods Female Humans Image Processing, Computer-Assisted Male Middle Aged Neuropsychological Tests Predictive Value of Tests
  • Pathology Brain Injuries
  • Complications Case-Control Studies Cognition Disorders
  • Diagnosis Diffusion Magnetic Resonance Imaging
  • Methods Female Humans Image Processing
  • Computer-Assisted
  • Male Middle Aged
  • Neuropsychological
  • Tests Predictive
  • Value of Tests

Cite this