Sib-TDT analysis of human TGF-beta1 gene single nucleotide polymorphisms in female twins: evidence for linkage and association with blood pressure at the codon 263 polymorphism

H. Snieder; E. J. C. G. van den Oord; M. Chiano; A. J. MacGregor; T. D. Spector

doi:10.1046/j.1466-9218.2000.00019.x

Sib-TDT analysis of human TGF-beta1 gene single nucleotide polymorphisms in female twins: evidence for linkage and association with blood pressure at the codon 263 polymorphism

H. Snieder, E. J. C. G. van den Oord, M. Chiano, A. J. MacGregor, T. D. Spector

Research output: Contribution to journal › Article

Abstract

We illustrate the use of a quantitative trait locus (QTL) association test with data on blood pressure and six single nucleotide polymorphisms (SNPs) within the transforming growth factor-β1(TGF-β1) gene in a large sample of dizygotic (DZ) twins. The test was specified within the framework of structural equation modelling and allows for population stratification and easily incorporates confounders. Results showed linkage in the presence of association between the TGF-β1 263 polymorphism and blood pressure levels, with carriers showing a clinically significant increase of 6 and 4 mm Hg in systolic and diastolic blood pressure, respectively. The described association test offers an easy and flexible way to analyse QTL data in sib or DZ twin pairs while controlling for population stratification by making use of within-family controls.

Original language	English
Pages (from-to)	89-91
Number of pages	3
Journal	Genescreen
Volume	1
Issue number	2
DOIs	https://doi.org/10.1046/j.1466-9218.2000.00019.x
Publication status	Published - Jul 2000

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10.1046/j.1466-9218.2000.00019.x

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title = "Sib-TDT analysis of human TGF-beta1 gene single nucleotide polymorphisms in female twins: evidence for linkage and association with blood pressure at the codon 263 polymorphism",

abstract = "We illustrate the use of a quantitative trait locus (QTL) association test with data on blood pressure and six single nucleotide polymorphisms (SNPs) within the transforming growth factor-β1(TGF-β1) gene in a large sample of dizygotic (DZ) twins. The test was specified within the framework of structural equation modelling and allows for population stratification and easily incorporates confounders. Results showed linkage in the presence of association between the TGF-β1 263 polymorphism and blood pressure levels, with carriers showing a clinically significant increase of 6 and 4 mm Hg in systolic and diastolic blood pressure, respectively. The described association test offers an easy and flexible way to analyse QTL data in sib or DZ twin pairs while controlling for population stratification by making use of within-family controls.",

author = "H. Snieder and {van den Oord}, {E. J. C. G.} and M. Chiano and MacGregor, {A. J.} and Spector, {T. D.}",

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journal = "Genescreen",

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T1 - Sib-TDT analysis of human TGF-beta1 gene single nucleotide polymorphisms in female twins: evidence for linkage and association with blood pressure at the codon 263 polymorphism

AU - Snieder, H.

AU - van den Oord, E. J. C. G.

AU - Chiano, M.

AU - MacGregor, A. J.

AU - Spector, T. D.

PY - 2000/7

Y1 - 2000/7

N2 - We illustrate the use of a quantitative trait locus (QTL) association test with data on blood pressure and six single nucleotide polymorphisms (SNPs) within the transforming growth factor-β1(TGF-β1) gene in a large sample of dizygotic (DZ) twins. The test was specified within the framework of structural equation modelling and allows for population stratification and easily incorporates confounders. Results showed linkage in the presence of association between the TGF-β1 263 polymorphism and blood pressure levels, with carriers showing a clinically significant increase of 6 and 4 mm Hg in systolic and diastolic blood pressure, respectively. The described association test offers an easy and flexible way to analyse QTL data in sib or DZ twin pairs while controlling for population stratification by making use of within-family controls.

AB - We illustrate the use of a quantitative trait locus (QTL) association test with data on blood pressure and six single nucleotide polymorphisms (SNPs) within the transforming growth factor-β1(TGF-β1) gene in a large sample of dizygotic (DZ) twins. The test was specified within the framework of structural equation modelling and allows for population stratification and easily incorporates confounders. Results showed linkage in the presence of association between the TGF-β1 263 polymorphism and blood pressure levels, with carriers showing a clinically significant increase of 6 and 4 mm Hg in systolic and diastolic blood pressure, respectively. The described association test offers an easy and flexible way to analyse QTL data in sib or DZ twin pairs while controlling for population stratification by making use of within-family controls.

U2 - 10.1046/j.1466-9218.2000.00019.x

DO - 10.1046/j.1466-9218.2000.00019.x

M3 - Article

SN - 1466-9218

VL - 1

SP - 89

EP - 91

JO - Genescreen

JF - Genescreen

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