Silencing human cancer: Identification and uses of microRNAs

Francisco Nicolas; Sara Lopez-Gomollon; Alfonso Lopez-Martinez; Tamas Dalmay

doi:10.2174/157489211793980033

Silencing human cancer: Identification and uses of microRNAs

Francisco Nicolas, Sara Lopez-Gomollon, Alfonso Lopez-Martinez, Tamas Dalmay

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are a new class of negative regulators that repress gene expression by pairing with their target messenger RNAs (mRNAs). There are hundreds of miRNAs coded in the human genome and thousands of target mRNAs participating in a wide variety of physiological processes such as development and cell identity. It is therefore not surprising that several recent reports involved deregulated miRNAs in the complex mechanism of human carcinogenesis, and proposed them as new key regulators to correct the unbalanced expression of oncogenes and tumour suppressor genes exhibited in cancer cells. This review summarises most of the recent patents related to the use of miRNA signatures in cancer diagnosis and prognosis, the detection and profiling of miRNAs from tumour samples and the identification of oncogenes and tumour suppressor genes targeted by miRNAs, as well as new cancer therapies based on miRNA modulators.

Original language	English
Pages (from-to)	94-105
Number of pages	12
Journal	Recent Patents on Anti-Cancer Drug Discovery
Volume	6
Issue number	1
DOIs	https://doi.org/10.2174/157489211793980033
Publication status	Published - 2011

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10.2174/157489211793980033

Cite this

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