Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

Sandra Palus, Stephan von Haehling, Valerie C Flach, Anika Tschirner, Wolfram Doehner, Stefan D Anker, Jochen Springer

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37 Citations (Scopus)

Abstract

Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.
Original languageEnglish
Pages (from-to)3412-8
Number of pages7
JournalInternational Journal of Cardiology
Volume168
Issue number4
DOIs
Publication statusPublished - 9 Oct 2013

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