Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

Sandra Palus; Stephan von Haehling; Valerie C Flach; Anika Tschirner; Wolfram Doehner; Stefan D Anker; Jochen Springer

doi:10.1016/j.ijcard.2013.04.150

Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

Sandra Palus, Stephan von Haehling, Valerie C Flach, Anika Tschirner, Wolfram Doehner, Stefan D Anker, Jochen Springer

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44 Citations (Scopus)

Abstract

Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.

Original language	English
Pages (from-to)	3412-8
Number of pages	7
Journal	International Journal of Cardiology
Volume	168
Issue number	4
DOIs	https://doi.org/10.1016/j.ijcard.2013.04.150
Publication status	Published - 9 Oct 2013

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10.1016/j.ijcard.2013.04.150

Cite this

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title = "Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia",

abstract = "Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.",

author = "Sandra Palus and {von Haehling}, Stephan and Flach, {Valerie C} and Anika Tschirner and Wolfram Doehner and Anker, {Stefan D} and Jochen Springer",

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AU - Palus, Sandra

AU - von Haehling, Stephan

AU - Flach, Valerie C

AU - Tschirner, Anika

AU - Doehner, Wolfram

AU - Anker, Stefan D

AU - Springer, Jochen

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AB - Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.

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DO - 10.1016/j.ijcard.2013.04.150

M3 - Article

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JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 1874-1754

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