Skin antisepsis in the neonate: What should we use?

Vennila Ponnusamy, Vidheya Venkatesh, Paul Clarke

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Neonates in intensive care are more susceptible to sepsis. Infection is commonly acquired via the transcutaneous portal. It is necessary to identify the most effective yet safest topical antiseptics for use in neonates to reduce nosocomial sepsis. RECENT FINDINGS: Recent national surveys indicate that a wide range of topical antiseptic preparations are used in the neonatal nursery. There are very few comparative studies in neonates and no robust evidence in favour of any particular antiseptic. There are significant safety and potential toxicity issues for neonates with all the commonly used antiseptics, particularly in very small immature babies. There are no convincing roles for routine application of emollient creams on the skin, topical antiseptics on the umbilical stump, or maternal vaginal washes with chlorhexidine for the prevention of neonatal infection. SUMMARY: Large multicentre trials are needed to determine the optimal antiseptic to use for neonates undergoing intensive care, especially for extremely preterm infants.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalCurrent Opinion in Infectious Diseases
Volume27
Issue number3
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • catheter-related sepsis
  • coagulase-negative staphylococcus
  • extraluminal colonization
  • nosocomial sepsis
  • percutaneous central venous catheters

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