Sleep and brain morphological changes in the eighth decade of life

Benjamin S. Aribisala; Renata L. Riha; Maria Valdez Hernandez; Susana Muñoz Maniega; Simon Cox; Ratko Radakovic; Adele Taylor; Alison Pattie; Janie Corley; Paul Redmond; Mark E. Bastin; John Starr; Ian Deary; Joanna M. Wardlaw

doi:10.1016/j.sleep.2019.07.015

Sleep and brain morphological changes in the eighth decade of life

Benjamin S. Aribisala, Renata L. Riha, Maria Valdez Hernandez, Susana Muñoz Maniega, Simon Cox, Ratko Radakovic, Adele Taylor, Alison Pattie, Janie Corley, Paul Redmond, Mark E. Bastin, John Starr, Ian Deary, Joanna M. Wardlaw

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Abstract

Objective: Sleep is important for brain health. We analysed associations between usual sleep habits and MRI markers of neurodegeneration (brain atrophy), vascular damage (white matter hyperintensities, WMH) and waste clearance (perivascular spaces, PVS) in older community-dwelling adults.

Method: We collected self-reported usual sleep duration, quality and medical histories from the Lothian Birth Cohort 1936 (LBC1936) age 76 years and performed brain MRI. We calculated sleep efficiency, measured WMH and brain volumes, quantified PVS, and assessed associations between sleep measures and brain markers in multivariate models adjusted for demographic and medical history variables.

Results: In 457 subjects (53% males, mean age 76±0.65 years), we found: brain and white matter loss with increased weekend daytime sleep (β=-0.114, P=0.03; β=-0.122, P=0.007 respectively), white matter loss with less efficient sleep (β=0.132, P=0.011) and PVS increased with interrupted sleep (OR 1.84 95% CI, P=0.025).

Conclusion: Cross-sectional associations of sleep parameters with brain atrophy and more PVS suggest adverse relationships between usual sleep habits and brain health in older people that should be evaluated longitudinally.

Original language	English
Pages (from-to)	152-158
Number of pages	7
Journal	Sleep Medicine Reviews
Volume	65
Early online date	24 Jul 2019
DOIs	https://doi.org/10.1016/j.sleep.2019.07.015
Publication status	Published - Jan 2020

Keywords

Ageing
Brain atrophy
Cerebrovascular disease
Magnetic resonance imaging
Perivascular spaces
Sleep
APNEA
SMALL VESSEL DISEASE
ASSOCIATIONS
QUALITY
WHITE-MATTER
SLOW-WAVE SLEEP
DWELLING OLDER-ADULTS
VIRCHOW-ROBIN SPACES
DURATION
AGE

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10.1016/j.sleep.2019.07.015

Accepted_ManuscriptAccepted author manuscript, 959 KBLicence: CC BY-NC-ND

https://linkinghub.elsevier.com/retrieve/pii/S1389945719302527

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title = "Sleep and brain morphological changes in the eighth decade of life",

abstract = "Objective: Sleep is important for brain health. We analysed associations between usual sleep habits and MRI markers of neurodegeneration (brain atrophy), vascular damage (white matter hyperintensities, WMH) and waste clearance (perivascular spaces, PVS) in older community-dwelling adults. Method: We collected self-reported usual sleep duration, quality and medical histories from the Lothian Birth Cohort 1936 (LBC1936) age 76 years and performed brain MRI. We calculated sleep efficiency, measured WMH and brain volumes, quantified PVS, and assessed associations between sleep measures and brain markers in multivariate models adjusted for demographic and medical history variables. Results: In 457 subjects (53% males, mean age 76±0.65 years), we found: brain and white matter loss with increased weekend daytime sleep (β=-0.114, P=0.03; β=-0.122, P=0.007 respectively), white matter loss with less efficient sleep (β=0.132, P=0.011) and PVS increased with interrupted sleep (OR 1.84 95% CI, P=0.025). Conclusion: Cross-sectional associations of sleep parameters with brain atrophy and more PVS suggest adverse relationships between usual sleep habits and brain health in older people that should be evaluated longitudinally.",

keywords = "Ageing, Brain atrophy, Cerebrovascular disease, Magnetic resonance imaging, Perivascular spaces, Sleep, APNEA, SMALL VESSEL DISEASE, ASSOCIATIONS, QUALITY, WHITE-MATTER, SLOW-WAVE SLEEP, DWELLING OLDER-ADULTS, VIRCHOW-ROBIN SPACES, DURATION, AGE",

author = "Aribisala, {Benjamin S.} and Riha, {Renata L.} and Hernandez, {Maria Valdez} and Maniega, {Susana Mu{\~n}oz} and Simon Cox and Ratko Radakovic and Adele Taylor and Alison Pattie and Janie Corley and Paul Redmond and Bastin, {Mark E.} and John Starr and Ian Deary and Wardlaw, {Joanna M.}",

year = "2020",

month = jan,

doi = "10.1016/j.sleep.2019.07.015",

language = "English",

volume = "65",

pages = "152--158",

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AU - Aribisala, Benjamin S.

AU - Riha, Renata L.

AU - Hernandez, Maria Valdez

AU - Maniega, Susana Muñoz

AU - Cox, Simon

AU - Radakovic, Ratko

AU - Taylor, Adele

AU - Pattie, Alison

AU - Corley, Janie

AU - Redmond, Paul

AU - Bastin, Mark E.

AU - Starr, John

AU - Deary, Ian

AU - Wardlaw, Joanna M.

PY - 2020/1

Y1 - 2020/1

N2 - Objective: Sleep is important for brain health. We analysed associations between usual sleep habits and MRI markers of neurodegeneration (brain atrophy), vascular damage (white matter hyperintensities, WMH) and waste clearance (perivascular spaces, PVS) in older community-dwelling adults. Method: We collected self-reported usual sleep duration, quality and medical histories from the Lothian Birth Cohort 1936 (LBC1936) age 76 years and performed brain MRI. We calculated sleep efficiency, measured WMH and brain volumes, quantified PVS, and assessed associations between sleep measures and brain markers in multivariate models adjusted for demographic and medical history variables. Results: In 457 subjects (53% males, mean age 76±0.65 years), we found: brain and white matter loss with increased weekend daytime sleep (β=-0.114, P=0.03; β=-0.122, P=0.007 respectively), white matter loss with less efficient sleep (β=0.132, P=0.011) and PVS increased with interrupted sleep (OR 1.84 95% CI, P=0.025). Conclusion: Cross-sectional associations of sleep parameters with brain atrophy and more PVS suggest adverse relationships between usual sleep habits and brain health in older people that should be evaluated longitudinally.

AB - Objective: Sleep is important for brain health. We analysed associations between usual sleep habits and MRI markers of neurodegeneration (brain atrophy), vascular damage (white matter hyperintensities, WMH) and waste clearance (perivascular spaces, PVS) in older community-dwelling adults. Method: We collected self-reported usual sleep duration, quality and medical histories from the Lothian Birth Cohort 1936 (LBC1936) age 76 years and performed brain MRI. We calculated sleep efficiency, measured WMH and brain volumes, quantified PVS, and assessed associations between sleep measures and brain markers in multivariate models adjusted for demographic and medical history variables. Results: In 457 subjects (53% males, mean age 76±0.65 years), we found: brain and white matter loss with increased weekend daytime sleep (β=-0.114, P=0.03; β=-0.122, P=0.007 respectively), white matter loss with less efficient sleep (β=0.132, P=0.011) and PVS increased with interrupted sleep (OR 1.84 95% CI, P=0.025). Conclusion: Cross-sectional associations of sleep parameters with brain atrophy and more PVS suggest adverse relationships between usual sleep habits and brain health in older people that should be evaluated longitudinally.

KW - Ageing

KW - Brain atrophy

KW - Cerebrovascular disease

KW - Magnetic resonance imaging

KW - Perivascular spaces

KW - Sleep

KW - APNEA

KW - SMALL VESSEL DISEASE

KW - ASSOCIATIONS

KW - QUALITY

KW - WHITE-MATTER

KW - SLOW-WAVE SLEEP

KW - DWELLING OLDER-ADULTS

KW - VIRCHOW-ROBIN SPACES

KW - DURATION

KW - AGE

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DO - 10.1016/j.sleep.2019.07.015

M3 - Article

VL - 65

SP - 152

EP - 158

JO - Sleep Medicine Reviews

JF - Sleep Medicine Reviews

SN - 1087-0792

ER -

Sleep and brain morphological changes in the eighth decade of life

Abstract

Keywords

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