Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients

Miklos Zsolt Molnar, Alpar Sandor Lazar, Anett Lindner, Katalin Fornadi, Maria Eszter Czira, Andrea Dunai, Rezso Zoller, Andras Szentkiralyi, Laszlo Rosivall, Colin Michael Shapiro, Marta Novak, Istvan Mucsi

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33 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVES: We assessed the prevalence of obstructive sleep apnea (OSA) and its clinical correlates in a large sample of patients who received a kidney transplant (Tx). We also compared the prevalence of the disorder between dialysis patients who were on the waiting list for a Tx (WL) and Tx patients.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a cross-sectional study of 100 Tx and 50 WL patients who underwent one-night polysomnography (SLeep disorders Evaluation in Patients after kidney Transplantation [SLEPT] Study). Sociodemographic information and data about medication, comorbidity, and laboratory parameters were collected.

RESULTS: The prevalence of mild (apnea-hypopnea index [AHI] > or =5/h and <15/h), moderate (AHI > or =15/h and <30/h), and severe OSA (AHI > or =30/h) was 18, 11, and 14% in the Tx group and 28, 16, and 10% in the WL group, respectively. The AHI was significantly correlated with age (rho = 0.34), body mass index (rho = 0.45), neck circumference (rho = 0.4), abdominal circumference (rho = 0.51), and hemoglobin (rho = 0.24) in the Tx group. The proportion of Tx patients who were treated with three or more antihypertensive drugs was significantly higher in the OSA group (56 versus 31%; P = 0.022). Despite taking significantly more antihypertensive drugs, the average systolic BP was still higher in patients with versus without OSA (147 +/- 21 versus 139 +/- 18 mmHg; P = 0.059).

CONCLUSIONS: The prevalence of OSA is similar in Tx and WL patients and it may contribute to presence of hypertension in patients who receive a Tx.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Cardiovascular Diseases
  • Cross-Sectional Studies
  • Female
  • Humans
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Postoperative Complications
  • Prevalence
  • Risk Factors
  • Obstructive Sleep Apnea
  • Waiting Lists

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