Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients

Miklos Zsolt Molnar; Alpar Sandor Lazar; Anett Lindner; Katalin Fornadi; Maria Eszter Czira; Andrea Dunai; Rezso Zoller; Andras Szentkiralyi; Laszlo Rosivall; Colin Michael Shapiro; Marta Novak; Istvan Mucsi

doi:10.2215/CJN.04030609

Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients

Miklos Zsolt Molnar, Alpar Sandor Lazar, Anett Lindner, Katalin Fornadi, Maria Eszter Czira, Andrea Dunai, Rezso Zoller, Andras Szentkiralyi, Laszlo Rosivall, Colin Michael Shapiro, Marta Novak, Istvan Mucsi

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND AND OBJECTIVES: We assessed the prevalence of obstructive sleep apnea (OSA) and its clinical correlates in a large sample of patients who received a kidney transplant (Tx). We also compared the prevalence of the disorder between dialysis patients who were on the waiting list for a Tx (WL) and Tx patients.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a cross-sectional study of 100 Tx and 50 WL patients who underwent one-night polysomnography (SLeep disorders Evaluation in Patients after kidney Transplantation [SLEPT] Study). Sociodemographic information and data about medication, comorbidity, and laboratory parameters were collected.

RESULTS: The prevalence of mild (apnea-hypopnea index [AHI] > or =5/h and <15/h), moderate (AHI > or =15/h and <30/h), and severe OSA (AHI > or =30/h) was 18, 11, and 14% in the Tx group and 28, 16, and 10% in the WL group, respectively. The AHI was significantly correlated with age (rho = 0.34), body mass index (rho = 0.45), neck circumference (rho = 0.4), abdominal circumference (rho = 0.51), and hemoglobin (rho = 0.24) in the Tx group. The proportion of Tx patients who were treated with three or more antihypertensive drugs was significantly higher in the OSA group (56 versus 31%; P = 0.022). Despite taking significantly more antihypertensive drugs, the average systolic BP was still higher in patients with versus without OSA (147 +/- 21 versus 139 +/- 18 mmHg; P = 0.059).

CONCLUSIONS: The prevalence of OSA is similar in Tx and WL patients and it may contribute to presence of hypertension in patients who receive a Tx.

Original language	English
Pages (from-to)	125-132
Number of pages	8
Journal	Clinical Journal of the American Society of Nephrology
Volume	5
Issue number	1
DOIs	https://doi.org/10.2215/CJN.04030609
Publication status	Published - Jan 2010

Keywords

Cardiovascular Diseases
Cross-Sectional Studies
Female
Humans
Kidney Transplantation
Male
Middle Aged
Postoperative Complications
Prevalence
Risk Factors
Obstructive Sleep Apnea
Waiting Lists

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2215/CJN.04030609

Cite this

Molnar, M. Z., Lazar, A. S., Lindner, A., Fornadi, K., Czira, M. E., Dunai, A., Zoller, R., Szentkiralyi, A., Rosivall, L., Shapiro, C. M., Novak, M., & Mucsi, I. (2010). Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients. Clinical Journal of the American Society of Nephrology, 5(1), 125-132. https://doi.org/10.2215/CJN.04030609

Molnar, Miklos Zsolt ; Lazar, Alpar Sandor ; Lindner, Anett ; Fornadi, Katalin ; Czira, Maria Eszter ; Dunai, Andrea ; Zoller, Rezso ; Szentkiralyi, Andras ; Rosivall, Laszlo ; Shapiro, Colin Michael ; Novak, Marta ; Mucsi, Istvan. / Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients. In: Clinical Journal of the American Society of Nephrology. 2010 ; Vol. 5, No. 1. pp. 125-132.

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abstract = "BACKGROUND AND OBJECTIVES: We assessed the prevalence of obstructive sleep apnea (OSA) and its clinical correlates in a large sample of patients who received a kidney transplant (Tx). We also compared the prevalence of the disorder between dialysis patients who were on the waiting list for a Tx (WL) and Tx patients.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a cross-sectional study of 100 Tx and 50 WL patients who underwent one-night polysomnography (SLeep disorders Evaluation in Patients after kidney Transplantation [SLEPT] Study). Sociodemographic information and data about medication, comorbidity, and laboratory parameters were collected.RESULTS: The prevalence of mild (apnea-hypopnea index [AHI] > or =5/h and <15/h), moderate (AHI > or =15/h and <30/h), and severe OSA (AHI > or =30/h) was 18, 11, and 14% in the Tx group and 28, 16, and 10% in the WL group, respectively. The AHI was significantly correlated with age (rho = 0.34), body mass index (rho = 0.45), neck circumference (rho = 0.4), abdominal circumference (rho = 0.51), and hemoglobin (rho = 0.24) in the Tx group. The proportion of Tx patients who were treated with three or more antihypertensive drugs was significantly higher in the OSA group (56 versus 31%; P = 0.022). Despite taking significantly more antihypertensive drugs, the average systolic BP was still higher in patients with versus without OSA (147 +/- 21 versus 139 +/- 18 mmHg; P = 0.059).CONCLUSIONS: The prevalence of OSA is similar in Tx and WL patients and it may contribute to presence of hypertension in patients who receive a Tx.",

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Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients. / Molnar, Miklos Zsolt; Lazar, Alpar Sandor; Lindner, Anett; Fornadi, Katalin; Czira, Maria Eszter; Dunai, Andrea; Zoller, Rezso; Szentkiralyi, Andras; Rosivall, Laszlo; Shapiro, Colin Michael; Novak, Marta; Mucsi, Istvan.

In: Clinical Journal of the American Society of Nephrology, Vol. 5, No. 1, 01.2010, p. 125-132.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients

AU - Molnar, Miklos Zsolt

AU - Lazar, Alpar Sandor

AU - Lindner, Anett

AU - Fornadi, Katalin

AU - Czira, Maria Eszter

AU - Dunai, Andrea

AU - Zoller, Rezso

AU - Szentkiralyi, Andras

AU - Rosivall, Laszlo

AU - Shapiro, Colin Michael

AU - Novak, Marta

AU - Mucsi, Istvan

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N2 - BACKGROUND AND OBJECTIVES: We assessed the prevalence of obstructive sleep apnea (OSA) and its clinical correlates in a large sample of patients who received a kidney transplant (Tx). We also compared the prevalence of the disorder between dialysis patients who were on the waiting list for a Tx (WL) and Tx patients.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a cross-sectional study of 100 Tx and 50 WL patients who underwent one-night polysomnography (SLeep disorders Evaluation in Patients after kidney Transplantation [SLEPT] Study). Sociodemographic information and data about medication, comorbidity, and laboratory parameters were collected.RESULTS: The prevalence of mild (apnea-hypopnea index [AHI] > or =5/h and <15/h), moderate (AHI > or =15/h and <30/h), and severe OSA (AHI > or =30/h) was 18, 11, and 14% in the Tx group and 28, 16, and 10% in the WL group, respectively. The AHI was significantly correlated with age (rho = 0.34), body mass index (rho = 0.45), neck circumference (rho = 0.4), abdominal circumference (rho = 0.51), and hemoglobin (rho = 0.24) in the Tx group. The proportion of Tx patients who were treated with three or more antihypertensive drugs was significantly higher in the OSA group (56 versus 31%; P = 0.022). Despite taking significantly more antihypertensive drugs, the average systolic BP was still higher in patients with versus without OSA (147 +/- 21 versus 139 +/- 18 mmHg; P = 0.059).CONCLUSIONS: The prevalence of OSA is similar in Tx and WL patients and it may contribute to presence of hypertension in patients who receive a Tx.

AB - BACKGROUND AND OBJECTIVES: We assessed the prevalence of obstructive sleep apnea (OSA) and its clinical correlates in a large sample of patients who received a kidney transplant (Tx). We also compared the prevalence of the disorder between dialysis patients who were on the waiting list for a Tx (WL) and Tx patients.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a cross-sectional study of 100 Tx and 50 WL patients who underwent one-night polysomnography (SLeep disorders Evaluation in Patients after kidney Transplantation [SLEPT] Study). Sociodemographic information and data about medication, comorbidity, and laboratory parameters were collected.RESULTS: The prevalence of mild (apnea-hypopnea index [AHI] > or =5/h and <15/h), moderate (AHI > or =15/h and <30/h), and severe OSA (AHI > or =30/h) was 18, 11, and 14% in the Tx group and 28, 16, and 10% in the WL group, respectively. The AHI was significantly correlated with age (rho = 0.34), body mass index (rho = 0.45), neck circumference (rho = 0.4), abdominal circumference (rho = 0.51), and hemoglobin (rho = 0.24) in the Tx group. The proportion of Tx patients who were treated with three or more antihypertensive drugs was significantly higher in the OSA group (56 versus 31%; P = 0.022). Despite taking significantly more antihypertensive drugs, the average systolic BP was still higher in patients with versus without OSA (147 +/- 21 versus 139 +/- 18 mmHg; P = 0.059).CONCLUSIONS: The prevalence of OSA is similar in Tx and WL patients and it may contribute to presence of hypertension in patients who receive a Tx.

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KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Kidney Transplantation

KW - Male

KW - Middle Aged

KW - Postoperative Complications

KW - Prevalence

KW - Risk Factors

KW - Obstructive Sleep Apnea

KW - Waiting Lists

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DO - 10.2215/CJN.04030609

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JO - Clinical Journal of the American Society of Nephrology

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