Small RNA analysis in Sindbis virus infected human HEK293 cells

Andras Donaszi-Ivanov, Irina Mohorianu, Tamas Dalmay, Penny P Powell

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Abstract

In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate. Since RNAi has a well-established role in controlling infection of the alphavirus Sindbis virus (SINV) in insects, we have used this virus to investigate the role of RNAi in SINV infection of human cells.
Original languageEnglish
Article numbere84070
JournalPLoS One
Volume8
Issue number12
DOIs
Publication statusPublished - 31 Dec 2013

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