Small RNA analysis in Sindbis virus infected human HEK293 cells

Andras Donaszi-Ivanov; Irina Mohorianu; Tamas Dalmay; Penny P Powell

doi:10.1371/journal.pone.0084070

Small RNA analysis in Sindbis virus infected human HEK293 cells

Andras Donaszi-Ivanov, Irina Mohorianu, Tamas Dalmay, Penny P Powell

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

19 Downloads (Pure)

Abstract

In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate. Since RNAi has a well-established role in controlling infection of the alphavirus Sindbis virus (SINV) in insects, we have used this virus to investigate the role of RNAi in SINV infection of human cells.

Original language	English
Article number	e84070
Journal	PLoS One
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0084070
Publication status	Published - 31 Dec 2013

Access to Document

10.1371/journal.pone.0084070

Donaszi-Ivanov_etal_2013_PLoSONEFinal published version, 1.27 MB

Pestivirus Evasion of the Intracellular Antiviral Response to Infection (Transfer of BBSRC Awardl)
Powell, P.
Biotechnology and Biological Sciences Research Council
1/07/07 → 31/08/09
Project: Research

Cite this

@article{4f530d53187f44faa12abe160c675404,

title = "Small RNA analysis in Sindbis virus infected human HEK293 cells",

abstract = "In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate. Since RNAi has a well-established role in controlling infection of the alphavirus Sindbis virus (SINV) in insects, we have used this virus to investigate the role of RNAi in SINV infection of human cells.",

author = "Andras Donaszi-Ivanov and Irina Mohorianu and Tamas Dalmay and Powell, {Penny P}",

note = "{\textcopyright} 2013 Donaszi-Ivanov et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2013",

month = dec,

day = "31",

doi = "10.1371/journal.pone.0084070",

language = "English",

volume = "8",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "12",

}

TY - JOUR

T1 - Small RNA analysis in Sindbis virus infected human HEK293 cells

AU - Donaszi-Ivanov, Andras

AU - Mohorianu, Irina

AU - Dalmay, Tamas

AU - Powell, Penny P

N1 - © 2013 Donaszi-Ivanov et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2013/12/31

Y1 - 2013/12/31

N2 - In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate. Since RNAi has a well-established role in controlling infection of the alphavirus Sindbis virus (SINV) in insects, we have used this virus to investigate the role of RNAi in SINV infection of human cells.

AB - In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate. Since RNAi has a well-established role in controlling infection of the alphavirus Sindbis virus (SINV) in insects, we have used this virus to investigate the role of RNAi in SINV infection of human cells.

U2 - 10.1371/journal.pone.0084070

DO - 10.1371/journal.pone.0084070

M3 - Article

C2 - 24391886

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e84070

ER -

Small RNA analysis in Sindbis virus infected human HEK293 cells

Abstract

Access to Document

Projects

Pestivirus Evasion of the Intracellular Antiviral Response to Infection (Transfer of BBSRC Awardl)

Cite this