Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota

Jane L Benjamin, Charlotte R H Hedin, Andreas Koutsoumpas, Siew C Ng, Neil E McCarthy, Natalie J Prescott, Pedro Pessoa-Lopes, Christopher G Mathew, Jeremy Sanderson, Ailsa L Hart, Michael A Kamm, Stella C Knight, Alastair Forbes, Andrew J Stagg, James O Lindsay, Kevin Whelan

Research output: Contribution to journalArticlepeer-review

118 Citations (Scopus)

Abstract

Patients with Crohn's disease (CD) have an intestinal dysbiosis with components of the microbiota exerting differential immune effects. Smoking is associated with an increased incidence of CD, more frequent relapse, and greater burden of surgery. This study aimed to investigate the association between smoking and the intestinal microbiota in patients with active CD.
Original languageEnglish
Pages (from-to)1092-100
Number of pages9
JournalInflammatory Bowel Diseases
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Adult
  • Case-Control Studies
  • Colony Count, Microbial
  • Crohn Disease
  • DNA, Bacterial
  • Feces
  • Female
  • Gastrointestinal Tract
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Metagenome
  • Prospective Studies
  • Smoking

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