SnoRNAs in cardiovascular development, function, and disease

Alzbeta Chabronova; Terri L. Holmes; Duc M. Hoang; Chris Denning; Victoria James; James G. W. Smith; Mandy J. Peffers

doi:10.1016/j.molmed.2024.03.004

SnoRNAs in cardiovascular development, function, and disease

Alzbeta Chabronova, Terri L. Holmes, Duc M. Hoang, Chris Denning, Victoria James, James G. W. Smith, Mandy J. Peffers

Research output: Contribution to journal › Review article › peer-review

Abstract

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).

Original language	English
Pages (from-to)	562-578
Number of pages	17
Journal	Trends in Molecular Medicine
Volume	30
Issue number	6
Early online date	23 Mar 2024
DOIs	https://doi.org/10.1016/j.molmed.2024.03.004
Publication status	Published - Jun 2024

Keywords

biomarker
cardiac fibrosis
cardiomyopathy
exercise
extracellular vesicles
snoRNA

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10.1016/j.molmed.2024.03.004Licence: CC BY

Cite this

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title = "SnoRNAs in cardiovascular development, function, and disease",

abstract = "Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).",

keywords = "biomarker, cardiac fibrosis, cardiomyopathy, exercise, extracellular vesicles, snoRNA",

author = "Alzbeta Chabronova and Holmes, {Terri L.} and Hoang, {Duc M.} and Chris Denning and Victoria James and Smith, {James G. W.} and Peffers, {Mandy J.}",

note = "Funding Information: Funding was received from the British Heart Foundation (SP/F/22/150044, CRMR/21/290009, and PG/21/10545) and Animal Free Research UK (AFR19-20293). The authors declare no competing interests. ",

year = "2024",

month = jun,

doi = "10.1016/j.molmed.2024.03.004",

language = "English",

volume = "30",

pages = "562--578",

journal = "Trends in Molecular Medicine",

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T1 - SnoRNAs in cardiovascular development, function, and disease

AU - Chabronova, Alzbeta

AU - Holmes, Terri L.

AU - Hoang, Duc M.

AU - Denning, Chris

AU - James, Victoria

AU - Smith, James G. W.

AU - Peffers, Mandy J.

N1 - Funding Information: Funding was received from the British Heart Foundation (SP/F/22/150044, CRMR/21/290009, and PG/21/10545) and Animal Free Research UK (AFR19-20293). The authors declare no competing interests.

PY - 2024/6

Y1 - 2024/6

N2 - Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).

AB - Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).

KW - biomarker

KW - cardiac fibrosis

KW - cardiomyopathy

KW - exercise

KW - extracellular vesicles

KW - snoRNA

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U2 - 10.1016/j.molmed.2024.03.004

DO - 10.1016/j.molmed.2024.03.004

M3 - Review article

VL - 30

SP - 562

EP - 578

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 6

ER -

SnoRNAs in cardiovascular development, function, and disease

Abstract

Keywords

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