SnoRNAs in cardiovascular development, function, and disease

Alzbeta Chabronova, Terri L. Holmes, Duc M. Hoang, Chris Denning, Victoria James, James G. W. Smith, Mandy J. Peffers

Research output: Contribution to journalReview articlepeer-review

Abstract

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).

Original languageEnglish
JournalTrends in Molecular Medicine
DOIs
Publication statusE-pub ahead of print - 23 Mar 2024

Keywords

  • biomarker
  • cardiac fibrosis
  • cardiomyopathy
  • exercise
  • extracellular vesicles
  • snoRNA

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