Socioeconomic, comorbidity, lifestyle and quality of life comparisons between chronic rhinosinusitis phenotypes

Carl Philpott, Tanya (Ngan Hong) Ta , Claire Hopkins, Jaydip Ray, Shazhada Ahmed, Robert Almeyda, Naveed Kara, Sean Carrie, Sally E. Erskine, Russell Cathcart, Vishnu Sunkaraneni, Alasdair Robertson, Shahram Anari, B. Nirmal Kumar, Allan Clark

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Background: Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory sinonasal disorders with key defining symptoms, but traditionally separated into phenotypes by clinical/endoscopic findings. It is not known whether the two phenotypes have differing socioeconomic, comorbidity, and lifestyle differences. This analysis of the Chronic Rhinosinusitis Epidemiology Study (CRES) database sought to analyze any key differences in the socioeconomic variables between those with CRS with nasal polyps (CRSwNPs) and those without nasal polyps (CRSsNPs). We also sought to analyze differences in comorbidities, lifestyle, and quality of life. Methods: Patients with a confirmed diagnosis of CRS in secondary and tertiary care outpatient settings in the UK were invited to participate in a questionnaire-based case–control study. Variables included demographics, socioeconomic factors, comorbidities, lifestyle factors, and health-related quality of life (HRQoL) (level 3 evidence). Results: A total of 1204 patients' data were analyzed: 553 CRSsNP and 651 CRSwNP participants. The key socioeconomic variables did not demonstrate any notable differences, nor did lifestyle variables other than alcohol consumption being higher in those with CRSwNP (P =.032), but the latter was not significant after adjusting for age and sex. Aside from confirmation of asthma being more common in CRSwNP, it was notable that this group complained less of upper respiratory tract infections (URTIs), and CRSsNP participants showed evidence of worse HRQoL scores in respect of body pain (P =.001). Conclusions: Patients with CRSwNP experience higher rates of asthma and lower rates of URTIs; patients with CRSsNP have worse body pain scores. Otherwise, there are no demonstrable significant socioeconomic, comorbidity, lifestyle, or quality of life differences between the two phenotypes. Level of evidence: 3 Laryngoscope, 2021.

Original languageEnglish
Pages (from-to)2179-2186
Number of pages8
JournalThe Laryngoscope
Issue number10
Early online date26 Mar 2021
Publication statusPublished - Oct 2021


  • Rhinosinusitis
  • comorbidity
  • lifestyle
  • quality of life
  • socioeconomic

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