Abstract
Original language | English |
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Pages (from-to) | 521-523 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 41 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2009 |
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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. / Van Haaften, Gijs; Dalgliesh, Gillian L; Davies, Helen; Chen, Lina; Bignell, Graham; Greenman, Christopher; Edkins, Sarah; Hardy, Claire; O'meara, Sarah; Teague, Jon; Butler, Adam; Hinton, Jonathan; Latimer, Calli; Andrews, Jenny; Barthorpe, Syd; Beare, Dave; Buck, Gemma; Campbell, Peter J; Cole, Jennifer; Forbes, Simon; Jia, Mingming; Jones, David; Kok, Chai Yin; Leroy, Catherine; Lin, Meng-lay; Mcbride, David J; Maddison, Mark; Maquire, Simon; Mclay, Kirsten; Menzies, Andrew; Mironenko, Tatiana; Mulderrig, Lee; Mudie, Laura; Pleasance, Erin; Shepherd, Rebecca; Smith, Raffaella; Stebbings, Lucy; Stephens, Philip; Tang, Gurpreet; Tarpey, Patrick S; Turner, Rachel; Turrell, Kelly; Varian, Jennifer; West, Sofie; Widaa, Sara; Wray, Paul; Collins, V Peter; Ichimura, Koichi; Law, Simon; Wong, John; Yuen, Siu Tsan; Leung, Suet Yi; Tonon, Giovanni; Depinho, Ronald A; Tai, Yu-tzu; Anderson, Kenneth C; Kahnoski, Richard J; Massie, Aaron; Khoo, Sok Kean; Teh, Bin Tean; Stratton, Michael R; Futreal, P Andrew.
In: Nature Genetics, Vol. 41, No. 5, 01.05.2009, p. 521-523.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
AU - Van Haaften, Gijs
AU - Dalgliesh, Gillian L
AU - Davies, Helen
AU - Chen, Lina
AU - Bignell, Graham
AU - Greenman, Christopher
AU - Edkins, Sarah
AU - Hardy, Claire
AU - O'meara, Sarah
AU - Teague, Jon
AU - Butler, Adam
AU - Hinton, Jonathan
AU - Latimer, Calli
AU - Andrews, Jenny
AU - Barthorpe, Syd
AU - Beare, Dave
AU - Buck, Gemma
AU - Campbell, Peter J
AU - Cole, Jennifer
AU - Forbes, Simon
AU - Jia, Mingming
AU - Jones, David
AU - Kok, Chai Yin
AU - Leroy, Catherine
AU - Lin, Meng-lay
AU - Mcbride, David J
AU - Maddison, Mark
AU - Maquire, Simon
AU - Mclay, Kirsten
AU - Menzies, Andrew
AU - Mironenko, Tatiana
AU - Mulderrig, Lee
AU - Mudie, Laura
AU - Pleasance, Erin
AU - Shepherd, Rebecca
AU - Smith, Raffaella
AU - Stebbings, Lucy
AU - Stephens, Philip
AU - Tang, Gurpreet
AU - Tarpey, Patrick S
AU - Turner, Rachel
AU - Turrell, Kelly
AU - Varian, Jennifer
AU - West, Sofie
AU - Widaa, Sara
AU - Wray, Paul
AU - Collins, V Peter
AU - Ichimura, Koichi
AU - Law, Simon
AU - Wong, John
AU - Yuen, Siu Tsan
AU - Leung, Suet Yi
AU - Tonon, Giovanni
AU - Depinho, Ronald A
AU - Tai, Yu-tzu
AU - Anderson, Kenneth C
AU - Kahnoski, Richard J
AU - Massie, Aaron
AU - Khoo, Sok Kean
AU - Teh, Bin Tean
AU - Stratton, Michael R
AU - Futreal, P Andrew
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
AB - Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
U2 - 10.1038/ng.349
DO - 10.1038/ng.349
M3 - Article
VL - 41
SP - 521
EP - 523
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 5
ER -