Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

Gijs Van Haaften, Gillian L Dalgliesh, Helen Davies, Lina Chen, Graham Bignell, Christopher Greenman, Sarah Edkins, Claire Hardy, Sarah O'meara, Jon Teague, Adam Butler, Jonathan Hinton, Calli Latimer, Jenny Andrews, Syd Barthorpe, Dave Beare, Gemma Buck, Peter J Campbell, Jennifer Cole, Simon ForbesMingming Jia, David Jones, Chai Yin Kok, Catherine Leroy, Meng-lay Lin, David J Mcbride, Mark Maddison, Simon Maquire, Kirsten Mclay, Andrew Menzies, Tatiana Mironenko, Lee Mulderrig, Laura Mudie, Erin Pleasance, Rebecca Shepherd, Raffaella Smith, Lucy Stebbings, Philip Stephens, Gurpreet Tang, Patrick S Tarpey, Rachel Turner, Kelly Turrell, Jennifer Varian, Sofie West, Sara Widaa, Paul Wray, V Peter Collins, Koichi Ichimura, Simon Law, John Wong, Siu Tsan Yuen, Suet Yi Leung, Giovanni Tonon, Ronald A Depinho, Yu-tzu Tai, Kenneth C Anderson, Richard J Kahnoski, Aaron Massie, Sok Kean Khoo, Bin Tean Teh, Michael R Stratton, P Andrew Futreal

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601 Citations (Scopus)

Abstract

Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
Original languageEnglish
Pages (from-to)521-523
Number of pages3
JournalNature Genetics
Volume41
Issue number5
DOIs
Publication statusPublished - 1 May 2009

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