Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

Bernard Malavaud; Dmitry Pchejetski; Catherine Mazerolles; Geisilène Russano de Paiva; Cyril Calvet; Nicolas Doumerc; Stuart Pitson; Pascal Rischmann; Olivier Cuvillier

doi:10.1016/j.ejca.2010.07.053

Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

Bernard Malavaud, Dmitry Pchejetski, Catherine Mazerolles, Geisilène Russano de Paiva, Cyril Calvet, Nicolas Doumerc, Stuart Pitson, Pascal Rischmann, Olivier Cuvillier

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in human prostate cancer. The present study was designed to assess SphK1 expression and activity in radical prostatectomy specimens and to research correlations with clinical features.

Original language	English
Pages (from-to)	3417-24
Number of pages	8
Journal	European Journal of Cancer
Volume	46
Issue number	18
DOIs	https://doi.org/10.1016/j.ejca.2010.07.053
Publication status	Published - Dec 2010

Keywords

Aged
Humans
Immunohistochemistry
Male
Microarray Analysis
Middle Aged
Neoplasm Proteins
Phosphotransferases (Alcohol Group Acceptor)
Prostatic Neoplasms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejca.2010.07.053

Cite this

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title = "Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens",

abstract = "Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in human prostate cancer. The present study was designed to assess SphK1 expression and activity in radical prostatectomy specimens and to research correlations with clinical features.",

keywords = "Aged, Humans, Immunohistochemistry, Male, Microarray Analysis, Middle Aged, Neoplasm Proteins, Phosphotransferases (Alcohol Group Acceptor), Prostatic Neoplasms",

author = "Bernard Malavaud and Dmitry Pchejetski and Catherine Mazerolles and {de Paiva}, {Geisil{\`e}ne Russano} and Cyril Calvet and Nicolas Doumerc and Stuart Pitson and Pascal Rischmann and Olivier Cuvillier",

year = "2010",

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doi = "10.1016/j.ejca.2010.07.053",

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T1 - Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

AU - Malavaud, Bernard

AU - Pchejetski, Dmitry

AU - Mazerolles, Catherine

AU - de Paiva, Geisilène Russano

AU - Calvet, Cyril

AU - Doumerc, Nicolas

AU - Pitson, Stuart

AU - Rischmann, Pascal

AU - Cuvillier, Olivier

PY - 2010/12

Y1 - 2010/12

N2 - Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in human prostate cancer. The present study was designed to assess SphK1 expression and activity in radical prostatectomy specimens and to research correlations with clinical features.

AB - Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in human prostate cancer. The present study was designed to assess SphK1 expression and activity in radical prostatectomy specimens and to research correlations with clinical features.

KW - Aged

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Microarray Analysis

KW - Middle Aged

KW - Neoplasm Proteins

KW - Phosphotransferases (Alcohol Group Acceptor)

KW - Prostatic Neoplasms

U2 - 10.1016/j.ejca.2010.07.053

DO - 10.1016/j.ejca.2010.07.053

M3 - Article

C2 - 20970322

VL - 46

SP - 3417

EP - 3424

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 18

ER -