Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

Bernard Malavaud, Dmitry Pchejetski, Catherine Mazerolles, Geisilène Russano de Paiva, Cyril Calvet, Nicolas Doumerc, Stuart Pitson, Pascal Rischmann, Olivier Cuvillier

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Abstract

Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in human prostate cancer. The present study was designed to assess SphK1 expression and activity in radical prostatectomy specimens and to research correlations with clinical features.
Original languageEnglish
Pages (from-to)3417-24
Number of pages8
JournalEuropean Journal of Cancer
Volume46
Issue number18
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Aged
  • Humans
  • Immunohistochemistry
  • Male
  • Microarray Analysis
  • Middle Aged
  • Neoplasm Proteins
  • Phosphotransferases (Alcohol Group Acceptor)
  • Prostatic Neoplasms

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