Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Tony I Venelinov, John H Beattie, Jack R Dainty, Wendy J Hollands, Susan J Fairweather-Tait, Linda J Harvey

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7 Citations (Scopus)


To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.
Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalJournal of Trace Elements in Medicine and Biology
Issue number2
Publication statusPublished - 1 Jun 2007


  • Albumins
  • Ceruloplasmin
  • Copper Radioisotopes
  • Humans
  • Pilot Projects
  • Plasma

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