Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Tony I Venelinov; John H Beattie; Jack R Dainty; Wendy J Hollands; Susan J Fairweather-Tait; Linda J Harvey

doi:10.1016/j.jtemb.2007.01.001

Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Tony I Venelinov
, John H Beattie
, Jack R Dainty
, Wendy J Hollands
, Susan J Fairweather-Tait
, Linda J Harvey

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.

Original language	English
Pages (from-to)	138-140
Number of pages	3
Journal	Journal of Trace Elements in Medicine and Biology
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.jtemb.2007.01.001
Publication status	Published - 1 Jun 2007

Keywords

Albumins
Ceruloplasmin
Copper Radioisotopes
Humans
Pilot Projects
Plasma

Access to Document

10.1016/j.jtemb.2007.01.001

http://dx.doi.org/10.1016/j.jtemb.2007.01.001

Cite this

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title = "Stable isotope pilot study of exchangeable copper kinetics in human blood plasma",

abstract = "To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.",

keywords = "Albumins, Ceruloplasmin, Copper Radioisotopes, Humans, Pilot Projects, Plasma",

author = "Venelinov, \{Tony I\} and Beattie, \{John H\} and Dainty, \{Jack R\} and Hollands, \{Wendy J\} and Fairweather-Tait, \{Susan J\} and Harvey, \{Linda J\}",

year = "2007",

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doi = "10.1016/j.jtemb.2007.01.001",

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T1 - Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

AU - Venelinov, Tony I

AU - Beattie, John H

AU - Dainty, Jack R

AU - Hollands, Wendy J

AU - Fairweather-Tait, Susan J

AU - Harvey, Linda J

PY - 2007/6/1

Y1 - 2007/6/1

N2 - To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.

AB - To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.

KW - Albumins

KW - Ceruloplasmin

KW - Copper Radioisotopes

KW - Humans

KW - Pilot Projects

KW - Plasma

U2 - 10.1016/j.jtemb.2007.01.001

DO - 10.1016/j.jtemb.2007.01.001

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SN - 0946-672X

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SP - 138

EP - 140

JO - Journal of Trace Elements in Medicine and Biology

JF - Journal of Trace Elements in Medicine and Biology

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ER -