Statin use is associated with reduced risk of histologic subtypes of esophageal cancer: A nested case-control analysis

Leo Alexandre, Allan B. Clark, Hina Y. Bhutta, Sean Holt, Michael P. N. Lewis, Andrew R. Hart

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Most patients with esophageal adenocarcinoma (EAC) or squamous cell cancer (ESCC) present with advanced, incurable disease. Statins have reported anti-carcinogenic effects and may be chemoprotective. We investigated the association between regular use of statins and the main histologic subtypes of esophageal malignancy (EAC, esophagogastric junctional adenocarcinoma [EGJA], and ESCC) in the UK general population.
Original languageEnglish
Pages (from-to)661–668
Number of pages8
Issue number3
Early online date5 Dec 2013
Publication statusPublished - Mar 2014


  • esophageal cancer
  • statins
  • aetiology

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