Statin use is associated with reduced risk of histologic subtypes of esophageal cancer: A nested case-control analysis

Leo Alexandre; Allan B. Clark; Hina Y. Bhutta; Sean Holt; Michael P. N. Lewis; Andrew R. Hart

doi:10.1053/j.gastro.2013.11.046

Statin use is associated with reduced risk of histologic subtypes of esophageal cancer: A nested case-control analysis

Leo Alexandre
, Allan B. Clark
, Hina Y. Bhutta
, Sean Holt
, Michael P. N. Lewis
, Andrew R. Hart

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

7 Downloads (Pure)

Abstract

Most patients with esophageal adenocarcinoma (EAC) or squamous cell cancer (ESCC) present with advanced, incurable disease. Statins have reported anti-carcinogenic effects and may be chemoprotective. We investigated the association between regular use of statins and the main histologic subtypes of esophageal malignancy (EAC, esophagogastric junctional adenocarcinoma [EGJA], and ESCC) in the UK general population.

Original language	English
Pages (from-to)	661–668
Number of pages	8
Journal	Gastroenterology
Volume	146
Issue number	3
Early online date	5 Dec 2013
DOIs	https://doi.org/10.1053/j.gastro.2013.11.046
Publication status	Published - Mar 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

esophageal cancer
statins
aetiology

Access to Document

10.1053/j.gastro.2013.11.046

Cite this

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abstract = "Most patients with esophageal adenocarcinoma (EAC) or squamous cell cancer (ESCC) present with advanced, incurable disease. Statins have reported anti-carcinogenic effects and may be chemoprotective. We investigated the association between regular use of statins and the main histologic subtypes of esophageal malignancy (EAC, esophagogastric junctional adenocarcinoma [EGJA], and ESCC) in the UK general population.",

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AU - Clark, Allan B.

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AU - Holt, Sean

AU - Lewis, Michael P. N.

AU - Hart, Andrew R.

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AB - Most patients with esophageal adenocarcinoma (EAC) or squamous cell cancer (ESCC) present with advanced, incurable disease. Statins have reported anti-carcinogenic effects and may be chemoprotective. We investigated the association between regular use of statins and the main histologic subtypes of esophageal malignancy (EAC, esophagogastric junctional adenocarcinoma [EGJA], and ESCC) in the UK general population.

KW - esophageal cancer

KW - statins

KW - aetiology

U2 - 10.1053/j.gastro.2013.11.046

DO - 10.1053/j.gastro.2013.11.046

M3 - Article

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