Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide

Marie‐Hélène David-Cordonnier, Maxwell Casely-Hayford, Mostafa Kouach, Gilbert Briand, Laurence H. Patterson, Christian Bailly, Mark Searcey

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Not like the rest. In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).
Original languageEnglish
Pages (from-to)1658–1661
Number of pages4
JournalChemBioChem
Volume7
Issue number11
DOIs
Publication statusPublished - 6 Nov 2006

Keywords

  • antitumor agents
  • azinomycin
  • depurination
  • DNA cleavage
  • natural products

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