Stress- (and diet-) related regulation of hepatic nuclear receptors and its relevance for ABC-transporter functions

Rinke Stienstra, Elgin Lichtenauer-Kaligis, Michael Müller

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Nuclear receptors (NRs) play an important role in maintaining cellular homeostasis. With clearly established roles in fatty acid metabolism and inflammation, peroxisome proliferator activated receptors (PPARs) and other nuclear receptors are essential in liver functioning. However, much less is known about the regulation of NRs themselves during inflammatory processes in the liver. Interestingly PPARs and other NRs are negative acute phase proteins because they become rapidly downregulated during the acute phase response. However, PPARs have important roles in modulating inflammatory responses. One of the mechanisms by which dietary or inflammatory stress is relieved involves the hepatic adenosine triphosphate-binding cassette (ABC) transporter proteins, which import and export a wide variety of substrates. These ABC transporters are under close control of several NRs. Because NRs play important roles in fatty acid metabolism and inflammation as well as in the regulation of bile production, they are reviewed here with respect to their role in dietary and stress-related responses of the liver and their impact on the regulation and function of hepatic ABC transporters.
Original languageEnglish
Pages (from-to)391-406
Number of pages16
JournalDrug Metabolism Reviews
Issue number2
Publication statusPublished - May 2004


  • ATP-Binding Cassette Transporters
  • Acute-Phase Reaction
  • Animals
  • Diet
  • Hepatitis
  • Humans
  • Liver
  • Liver Cirrhosis
  • Peroxisome Proliferator-Activated Receptors
  • Receptors, Cytoplasmic and Nuclear
  • Stress, Physiological

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