Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure.

Anja Sandek, Ingvar Bjarnason, Hans-Dieter Volk, Roger Crane, Jonathan B Meddings, Josef Niebauer, Paul R Kalra, Sabine Buhner, Ralph Herrmann, Jochen Springer, Wolfram Doehner, Stephan von Haehling, Stefan D Anker, Mathias Rauchhaus

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134 Citations (SciVal)

Abstract

BACKGROUND: Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF. METHODS: We measured intestinal permeability (melibiose and rhamnose), active (3-O-methyl-d-glucose (3-OMG)) and passive (d-xylose) carrier-mediated absorption in 20 CHF patients (12 edematous and 8 non-edematous) and 8 controls by saccharide absorption technique assessing urinary recovery of orally administered sugars. We additionally measured LPS concentrations in 42 patients with decompensated heart failure and after recompensation. RESULTS: CHF patients had a 54% reduction of active carrier-mediated intestinal transport compared to controls (p
Original languageEnglish
Pages (from-to)80–85
JournalInternational Journal of Cardiology
Volume157
Issue number1
Early online date27 Dec 2010
DOIs
Publication statusPublished - 17 May 2012

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