Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure.

Anja Sandek; Ingvar Bjarnason; Hans-Dieter Volk; Roger Crane; Jonathan B Meddings; Josef Niebauer; Paul R Kalra; Sabine Buhner; Ralph Herrmann; Jochen Springer; Wolfram Doehner; Stephan von Haehling; Stefan D Anker; Mathias Rauchhaus

doi:10.1016/j.ijcard.2010.12.016

Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure.

Anja Sandek
, Ingvar Bjarnason
, Hans-Dieter Volk
, Roger Crane
, Jonathan B Meddings
, Josef Niebauer
, Paul R Kalra
, Sabine Buhner
, Ralph Herrmann
, Jochen Springer
, Wolfram Doehner
, Stephan von Haehling
, Stefan D Anker
, Mathias Rauchhaus

Research output: Contribution to journal › Article

230 Citations (Scopus)

Abstract

BACKGROUND: Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF. METHODS: We measured intestinal permeability (melibiose and rhamnose), active (3-O-methyl-d-glucose (3-OMG)) and passive (d-xylose) carrier-mediated absorption in 20 CHF patients (12 edematous and 8 non-edematous) and 8 controls by saccharide absorption technique assessing urinary recovery of orally administered sugars. We additionally measured LPS concentrations in 42 patients with decompensated heart failure and after recompensation. RESULTS: CHF patients had a 54% reduction of active carrier-mediated intestinal transport compared to controls (p

Original language	English
Pages (from-to)	80–85
Journal	International Journal of Cardiology
Volume	157
Issue number	1
Early online date	27 Dec 2010
DOIs	https://doi.org/10.1016/j.ijcard.2010.12.016
Publication status	Published - 17 May 2012

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10.1016/j.ijcard.2010.12.016

Cite this

Sandek, A., Bjarnason, I., Volk, H.-D., Crane, R., Meddings, J. B., Niebauer, J., Kalra, P. R., Buhner, S., Herrmann, R., Springer, J., Doehner, W., von Haehling, S., Anker, S. D., & Rauchhaus, M. (2012). Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure. International Journal of Cardiology, 157(1), 80–85. https://doi.org/10.1016/j.ijcard.2010.12.016

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title = "Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure.",

abstract = "BACKGROUND: Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF. METHODS: We measured intestinal permeability (melibiose and rhamnose), active (3-O-methyl-d-glucose (3-OMG)) and passive (d-xylose) carrier-mediated absorption in 20 CHF patients (12 edematous and 8 non-edematous) and 8 controls by saccharide absorption technique assessing urinary recovery of orally administered sugars. We additionally measured LPS concentrations in 42 patients with decompensated heart failure and after recompensation. RESULTS: CHF patients had a 54\% reduction of active carrier-mediated intestinal transport compared to controls (p",

author = "Anja Sandek and Ingvar Bjarnason and Hans-Dieter Volk and Roger Crane and Meddings, \{Jonathan B\} and Josef Niebauer and Kalra, \{Paul R\} and Sabine Buhner and Ralph Herrmann and Jochen Springer and Wolfram Doehner and \{von Haehling\}, Stephan and Anker, \{Stefan D\} and Mathias Rauchhaus",

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doi = "10.1016/j.ijcard.2010.12.016",

language = "English",

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Sandek, A, Bjarnason, I, Volk, H-D, Crane, R, Meddings, JB, Niebauer, J, Kalra, PR, Buhner, S, Herrmann, R, Springer, J, Doehner, W, von Haehling, S, Anker, SD & Rauchhaus, M 2012, 'Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure.', International Journal of Cardiology, vol. 157, no. 1, pp. 80–85. https://doi.org/10.1016/j.ijcard.2010.12.016

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T1 - Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure.

AU - Sandek, Anja

AU - Bjarnason, Ingvar

AU - Volk, Hans-Dieter

AU - Crane, Roger

AU - Meddings, Jonathan B

AU - Niebauer, Josef

AU - Kalra, Paul R

AU - Buhner, Sabine

AU - Herrmann, Ralph

AU - Springer, Jochen

AU - Doehner, Wolfram

AU - von Haehling, Stephan

AU - Anker, Stefan D

AU - Rauchhaus, Mathias

PY - 2012/5/17

Y1 - 2012/5/17

N2 - BACKGROUND: Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF. METHODS: We measured intestinal permeability (melibiose and rhamnose), active (3-O-methyl-d-glucose (3-OMG)) and passive (d-xylose) carrier-mediated absorption in 20 CHF patients (12 edematous and 8 non-edematous) and 8 controls by saccharide absorption technique assessing urinary recovery of orally administered sugars. We additionally measured LPS concentrations in 42 patients with decompensated heart failure and after recompensation. RESULTS: CHF patients had a 54% reduction of active carrier-mediated intestinal transport compared to controls (p

AB - BACKGROUND: Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF. METHODS: We measured intestinal permeability (melibiose and rhamnose), active (3-O-methyl-d-glucose (3-OMG)) and passive (d-xylose) carrier-mediated absorption in 20 CHF patients (12 edematous and 8 non-edematous) and 8 controls by saccharide absorption technique assessing urinary recovery of orally administered sugars. We additionally measured LPS concentrations in 42 patients with decompensated heart failure and after recompensation. RESULTS: CHF patients had a 54% reduction of active carrier-mediated intestinal transport compared to controls (p

U2 - 10.1016/j.ijcard.2010.12.016

DO - 10.1016/j.ijcard.2010.12.016

M3 - Article

SN - 1874-1754

VL - 157

SP - 80

EP - 85

JO - International Journal of Cardiology

JF - International Journal of Cardiology

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