Study protocol to investigate the effects of testosterone therapy as an adjunct to exercise rehabilitation in hypogonadal males with chronic heart failure

John M Saxton, Irena Zwierska, Atish Mathur, Kevin S Channer

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12 Citations (Scopus)


Testosterone deficiency is a common occurrence in men with chronic heart failure (CHF) and may underpin features of advanced disease, including reduced skeletal muscle mass and fatigue. It is positively correlated with cardiac output and exercise capacity in patients with CHF, whereas a significant improvement in both these parameters has been observed following testosterone replacement therapy. Testosterone therapy has also been shown to reduce circulating levels of inflammatory markers, (TNF-alpha, sICAM-1 and sVCAM-1) in patients with established coronary artery disease and testosterone deficiency. This pilot study will assess the feasibility of a combined exercise rehabilitation and adjunctive testosterone therapy intervention for evoking improvements in exercise capacity, circulating inflammatory markers, cardiac and skeletal muscle function, indices of psychological health status and quality of life in hypogonadal males with chronic heart failure.
Original languageEnglish
Article number46
JournalBMC Cardiovascular Disorders
Publication statusPublished - 30 Nov 2006


  • Cell Adhesion Molecules
  • Clinical Protocols
  • Combined Modality Therapy
  • Comorbidity
  • Exercise Test
  • Exercise Therapy
  • Exercise Tolerance
  • Health Status
  • Heart Failure
  • Humans
  • Hypogonadism
  • Inflammation Mediators
  • Male
  • Physical Endurance
  • Pilot Projects
  • Quality of Life
  • Randomized Controlled Trials as Topic
  • Testosterone

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