@article{8b737587236541308c48dc9c83e4fbfa,
title = "Subcellular mRNA localization regulates ribosome biogenesis in migrating cells",
abstract = "Dermit et al. reveal that ribosomal protein (RP)-mRNAs localize to the protrusive fronts of migratory cells, where their translation is locally increased, leading to upregulation of ribosome biogenesis and protein synthesis. In aggressive carcinomas, this pathway is upregulated in order to support the high anabolic demands of invasive cancer cells.",
keywords = "cancer, EMT, invasion, La-related proteins, LARP6, protrusion, ribosomal proteins, ribosome biogenesis, RNA localization",
author = "Maria Dermit and Martin Dodel and Lee, {Flora C. Y.} and Azman, {Muhammad S.} and Hagen Schwenzer and Jones, {J. Louise} and Blagden, {Sarah P.} and Jernej Ule and Mardakheh, {Faraz K.}",
note = "Acknowledgements: We would like to thank Carme Gallego, Antonio Gentilella, Andrew Yoo, and Robert Weinberg for plasmids as well as Carme Gallego, Sara Santos, and Anne Willis for advice on the experiments. Sequencing of the iCLIP libraries was carried out at the Crick Advanced Sequencing platform. All other RNA-seq sequencings were carried out at the Barts and the London Genome Center. We also wish to acknowledge the role of the Breast Cancer Now Tissue Bank in collecting and making available the human breast tissue samples used in the generation of this publication. Finally, our special thanks goes to Christopher Tape, Lovorka Stojic, and Sarah McClelland for critical reading of the manuscript. Funding Information: This work was funded by a Medical Research Council (United Kingdom) Career Development Award (MR/P009417/1) and a Barts Charity grant ( MGU0346 ) to F.K.M., and a European Research Council grant (European Union) under the EU's Seventh Framework Programme ( 617837 -Translate) to J.U. ",
year = "2020",
month = nov,
day = "9",
doi = "10.1016/j.devcel.2020.10.006",
language = "English",
volume = "55",
pages = "298--313.e10",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "3",
}
