Subcellular mRNA localization regulates ribosome biogenesis in migrating cells

Maria Dermit, Martin Dodel, Flora C. Y. Lee, Muhammad S. Azman, Hagen Schwenzer, J. Louise Jones, Sarah P. Blagden, Jernej Ule, Faraz K. Mardakheh

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Dermit et al. reveal that ribosomal protein (RP)-mRNAs localize to the protrusive fronts of migratory cells, where their translation is locally increased, leading to upregulation of ribosome biogenesis and protein synthesis. In aggressive carcinomas, this pathway is upregulated in order to support the high anabolic demands of invasive cancer cells.

Original languageEnglish
Pages (from-to)298-313.e10
Number of pages16
JournalDevelopmental Cell
Volume55
Issue number3
DOIs
Publication statusPublished - 9 Nov 2020

Keywords

  • cancer
  • EMT
  • invasion
  • La-related proteins
  • LARP6
  • protrusion
  • ribosomal proteins
  • ribosome biogenesis
  • RNA localization

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