Substance use, medication adherence and outcome one year following a first episode of psychosis

Marco Colizzi; Elena Carra; Sara Fraietta; John Lally; Diego Quattrone; Stefania Bonaccorso; Valeria Mondelli; Olesya Ajnakina; Paola Dazzan; Antonella Trotta; Lucia Sideli; Anna Kolliakou; Fiona Gaughran; Mizanur Khondoker; Anthony S. David; Robin M. Murray; James H. MacCabe; Marta Di Forti

doi:10.1016/j.schres.2015.11.016

Substance use, medication adherence and outcome one year following a first episode of psychosis

Marco Colizzi, Elena Carra, Sara Fraietta, John Lally, Diego Quattrone, Stefania Bonaccorso, Valeria Mondelli, Olesya Ajnakina, Paola Dazzan, Antonella Trotta, Lucia Sideli, Anna Kolliakou, Fiona Gaughran, Mizanur Khondoker, Anthony S. David, Robin M. Murray, James H. MacCabe, Marta Di Forti

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other. (C) 2015 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	311-317
Number of pages	7
Journal	Schizophrenia Research
Volume	170
Issue number	2-3
Early online date	21 Dec 2015
DOIs	https://doi.org/10.1016/j.schres.2015.11.016
Publication status	Published - Feb 2016

Keywords

First episode psychosis
Substance use
Cannabis use
Nicotine dependence
Medication adherence
Remission

Access to Document

10.1016/j.schres.2015.11.016

Cite this

Colizzi, M., Carra, E., Fraietta, S., Lally, J., Quattrone, D., Bonaccorso, S., Mondelli, V., Ajnakina, O., Dazzan, P., Trotta, A., Sideli, L., Kolliakou, A., Gaughran, F., Khondoker, M., David, A. S., Murray, R. M., MacCabe, J. H., & Di Forti, M. (2016). Substance use, medication adherence and outcome one year following a first episode of psychosis. Schizophrenia Research, 170(2-3), 311-317. https://doi.org/10.1016/j.schres.2015.11.016

Colizzi, Marco ; Carra, Elena ; Fraietta, Sara ; Lally, John ; Quattrone, Diego ; Bonaccorso, Stefania ; Mondelli, Valeria ; Ajnakina, Olesya ; Dazzan, Paola ; Trotta, Antonella ; Sideli, Lucia ; Kolliakou, Anna ; Gaughran, Fiona ; Khondoker, Mizanur ; David, Anthony S. ; Murray, Robin M. ; MacCabe, James H. ; Di Forti, Marta. / Substance use, medication adherence and outcome one year following a first episode of psychosis. In: Schizophrenia Research. 2016 ; Vol. 170, No. 2-3. pp. 311-317.

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abstract = "Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other. (C) 2015 Elsevier B.V. All rights reserved.",

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author = "Marco Colizzi and Elena Carra and Sara Fraietta and John Lally and Diego Quattrone and Stefania Bonaccorso and Valeria Mondelli and Olesya Ajnakina and Paola Dazzan and Antonella Trotta and Lucia Sideli and Anna Kolliakou and Fiona Gaughran and Mizanur Khondoker and David, {Anthony S.} and Murray, {Robin M.} and MacCabe, {James H.} and {Di Forti}, Marta",

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Colizzi, M, Carra, E, Fraietta, S, Lally, J, Quattrone, D, Bonaccorso, S, Mondelli, V, Ajnakina, O, Dazzan, P, Trotta, A, Sideli, L, Kolliakou, A, Gaughran, F, Khondoker, M, David, AS, Murray, RM, MacCabe, JH & Di Forti, M 2016, 'Substance use, medication adherence and outcome one year following a first episode of psychosis', Schizophrenia Research, vol. 170, no. 2-3, pp. 311-317. https://doi.org/10.1016/j.schres.2015.11.016

Substance use, medication adherence and outcome one year following a first episode of psychosis. / Colizzi, Marco; Carra, Elena; Fraietta, Sara; Lally, John; Quattrone, Diego; Bonaccorso, Stefania; Mondelli, Valeria; Ajnakina, Olesya; Dazzan, Paola; Trotta, Antonella; Sideli, Lucia; Kolliakou, Anna; Gaughran, Fiona; Khondoker, Mizanur; David, Anthony S.; Murray, Robin M.; MacCabe, James H.; Di Forti, Marta.

In: Schizophrenia Research, Vol. 170, No. 2-3, 02.2016, p. 311-317.

Research output: Contribution to journal › Article › peer-review

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AU - Colizzi, Marco

AU - Carra, Elena

AU - Fraietta, Sara

AU - Lally, John

AU - Quattrone, Diego

AU - Bonaccorso, Stefania

AU - Mondelli, Valeria

AU - Ajnakina, Olesya

AU - Dazzan, Paola

AU - Trotta, Antonella

AU - Sideli, Lucia

AU - Kolliakou, Anna

AU - Gaughran, Fiona

AU - Khondoker, Mizanur

AU - David, Anthony S.

AU - Murray, Robin M.

AU - MacCabe, James H.

AU - Di Forti, Marta

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AB - Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other. (C) 2015 Elsevier B.V. All rights reserved.

KW - First episode psychosis

KW - Substance use

KW - Cannabis use

KW - Nicotine dependence

KW - Medication adherence

KW - Remission

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DO - 10.1016/j.schres.2015.11.016

M3 - Article

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SP - 311

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JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

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