Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMR

Francesca Piana, David H. Case, Susana Campos E Menezes Jorge Ramalhete, Giuseppe Pileio, Marco Facciotti, Graeme M. Day (Lead Author), Yaroslav Khimyak (Lead Author), Jesus Angulo, Richard C. D. Brown, Philip A. Gale (Lead Author)

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Abstract

Eighteen N-aryl-N'-alkyl urea gelators were synthesised in order to understand the effect of head substituents on gelation performance. Minimum gelation concentration values obtained from gel formation studies were used to rank the compounds and revealed the remarkable performance of 4-methoxyphenyl urea gelator 15 in comparison to 4-nitrophenyl analogue 14, which could not be simply ascribed to substituent effects on the hydrogen bonding capabilities of the urea protons. Crystal structure prediction calculations indicated alternative low energy hydrogen bonding arrangements between the nitro group and urea protons in gelator 14, which were supported experimentally by NMR spectroscopy. As a consequence, it was possible to relate the observed differences to interference of the head substituents with the urea tape motif, disrupting the order of supramolecular packing. The combination of unbiased structure prediction calculations with NMR is proposed as a powerful approach
to investigate the supramolecular arrangement in gel fibres and help understand the relationships between molecular structure and gel formation.
Original languageEnglish
Pages (from-to)4034-4043
Number of pages12
JournalSoft Matter
Volume12
Issue number17
Early online date29 Mar 2016
DOIs
Publication statusPublished - 7 May 2016

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