Sudden cardiac death and inherited channelopathy: The basic electrophysiology of the myocyte and myocardium in ion channel disease

Claire A. Martin, Gareth D.K. Matthews, Christopher L.H. Huang

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)

Abstract

Mutations involving cardiac ion channels result in abnormal action potential formation or propagation, leading to cardiac arrhythmias. Despite the large impact on society of sudden cardiac death resulting from such arrhythmias, understanding of the underlying cellular mechanism is poor and clinical risk stratification and treatment consequently limited. Basic research using molecular techniques, as well as animal models, has proved extremely useful in improving our knowledge of inherited arrhythmogenic syndromes. This offers the practitioner tools to accurately diagnose rare disorders and provides novel markers for risk assessment and a basis for new strategies of treatment.

Original languageEnglish
Pages (from-to)536-543
Number of pages8
JournalHeart
Volume98
Issue number7
DOIs
Publication statusPublished - Apr 2012

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