Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Rose K. Davidson, Orla Jupp, Rachel de Ferrars, Colin D. Kay, Kirsty L Culley, Rosemary Norton, Clare Driscoll, Tonia L. Vincent, Simon T. Donell, Yongping Bao, Ian M. Clark

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Abstract

Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block cartilage destruction in osteoarthritis.
Original languageEnglish
Pages (from-to)3130-3140
Number of pages11
JournalArthritis and Rheumatism
Volume65
Issue number12
Early online date27 Aug 2013
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Animals
  • Arthritis, Experimental
  • Cartilage, Articular
  • Cattle
  • Chondrocytes
  • Humans
  • Isothiocyanates
  • Matrix Metalloproteinases
  • Mice
  • NF-E2-Related Factor 2
  • NF-kappa B
  • Osteoarthritis
  • Signal Transduction

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