Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Rose K. Davidson; Orla Jupp; Rachel de Ferrars; Colin D. Kay; Kirsty L Culley; Rosemary Norton; Clare Driscoll; Tonia L. Vincent; Simon T. Donell; Yongping Bao; Ian M. Clark

doi:10.1002/art.38133

Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Rose K. Davidson, Orla Jupp, Rachel de Ferrars, Colin D. Kay, Kirsty L Culley, Rosemary Norton, Clare Driscoll, Tonia L. Vincent, Simon T. Donell, Yongping Bao, Ian M. Clark

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Abstract

Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block cartilage destruction in osteoarthritis.

Original language	English
Pages (from-to)	3130-3140
Number of pages	11
Journal	Arthritis and Rheumatism
Volume	65
Issue number	12
Early online date	27 Aug 2013
DOIs	https://doi.org/10.1002/art.38133
Publication status	Published - Dec 2013

Keywords

Animals
Arthritis, Experimental
Cartilage, Articular
Cattle
Chondrocytes
Humans
Isothiocyanates
Matrix Metalloproteinases
Mice
NF-E2-Related Factor 2
NF-kappa B
Osteoarthritis
Signal Transduction

Access to Document

10.1002/art.38133

Davidson_etal_2013_AandR
© 2013 The Authors. Arthritis & Rheumatism is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Cite this

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title = "Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo",

abstract = "Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block cartilage destruction in osteoarthritis.",

keywords = "Animals, Arthritis, Experimental, Cartilage, Articular, Cattle, Chondrocytes, Humans, Isothiocyanates, Matrix Metalloproteinases, Mice, NF-E2-Related Factor 2, NF-kappa B, Osteoarthritis, Signal Transduction",

author = "Davidson, {Rose K.} and Orla Jupp and {de Ferrars}, Rachel and Kay, {Colin D.} and Culley, {Kirsty L} and Rosemary Norton and Clare Driscoll and Vincent, {Tonia L.} and Donell, {Simon T.} and Yongping Bao and Clark, {Ian M.}",

note = "Funded by: Biotechnology and Biological Sciences Research Council (Diet and Health Research Industry Club). Grant Number: BB/I006060/1; Dunhill Medical Trust. Grant Number: R73/0208; Arthritis Research UK. Grant Number: 19371",

year = "2013",

month = dec,

doi = "10.1002/art.38133",

language = "English",

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AU - Davidson, Rose K.

AU - Jupp, Orla

AU - de Ferrars, Rachel

AU - Kay, Colin D.

AU - Culley, Kirsty L

AU - Norton, Rosemary

AU - Driscoll, Clare

AU - Vincent, Tonia L.

AU - Donell, Simon T.

AU - Bao, Yongping

AU - Clark, Ian M.

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KW - Animals

KW - Arthritis, Experimental

KW - Cartilage, Articular

KW - Cattle

KW - Chondrocytes

KW - Humans

KW - Isothiocyanates

KW - Matrix Metalloproteinases

KW - Mice

KW - NF-E2-Related Factor 2

KW - NF-kappa B

KW - Osteoarthritis

KW - Signal Transduction

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