Superior performance of macroporous over gel type polystyrene as a support for the development of photo-bactericidal materials

Carles Felip-León; Carla Arnau Del Valle; Vanesa Pérez-Laguna; María Isabel Millán-Lou; Juan F. Miravet; Maxim Mikhailov; Maxim N. Sokolov; Antonio Rezusta-López; Francisco Galindo

doi:10.1039/C7TB01478C

Superior performance of macroporous over gel type polystyrene as a support for the development of photo-bactericidal materials

Carles Felip-León, Carla Arnau Del Valle, Vanesa Pérez-Laguna, María Isabel Millán-Lou, Juan F. Miravet, Maxim Mikhailov, Maxim N. Sokolov, Antonio Rezusta-López, Francisco Galindo

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

A hexanuclear molybdenum cluster [Mo₆I₈Ac₆]²⁻ (1) has been ionically bound onto macroporous (P_mp) and gel-type (P_gel) resins and their performance as materials for the photodynamic inactivation of microorganisms has been studied. It has been found that 1@P_mp in combination with light is able to reduce 99.999999% of the population of Gram-positive Staphylococcus aureus whereas the activity of 1@P_gel is limited to a 99.99% reduction at the same light dose. The same trend is observed with Gram-negative Pseudomonas aeruginosa. A comprehensive study of both materials has been performed using confocal laser scanning microscopy, thermogravimetric analysis, nitrogen porosimetry, steady state and time resolved fluorometries and diffuse reflectance spectroscopy. The photochemical generation of singlet oxygen (¹O₂) has been assessed using 9,10-dimethylanthracene as a trap for this reactive oxygen species. It can be concluded that the nature of the polymeric support is of paramount importance for the development of surfaces with bactericidal properties.

Original language	English
Pages (from-to)	6058-6064
Number of pages	7
Journal	Journal of Materials Chemistry B
Volume	5
DOIs	https://doi.org/10.1039/C7TB01478C
Publication status	Published - 20 Jul 2017

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10.1039/C7TB01478C

Cite this

Felip-León, C., Arnau Del Valle, C., Pérez-Laguna, V., Millán-Lou, M. I., Miravet, J. F., Mikhailov, M., Sokolov, M. N., Rezusta-López, A., & Galindo, F. (2017). Superior performance of macroporous over gel type polystyrene as a support for the development of photo-bactericidal materials. Journal of Materials Chemistry B, 5, 6058-6064. https://doi.org/10.1039/C7TB01478C

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title = "Superior performance of macroporous over gel type polystyrene as a support for the development of photo-bactericidal materials",

abstract = "A hexanuclear molybdenum cluster [Mo6I8Ac6]2− (1) has been ionically bound onto macroporous (Pmp) and gel-type (Pgel) resins and their performance as materials for the photodynamic inactivation of microorganisms has been studied. It has been found that 1@Pmp in combination with light is able to reduce 99.999999% of the population of Gram-positive Staphylococcus aureus whereas the activity of 1@Pgel is limited to a 99.99% reduction at the same light dose. The same trend is observed with Gram-negative Pseudomonas aeruginosa. A comprehensive study of both materials has been performed using confocal laser scanning microscopy, thermogravimetric analysis, nitrogen porosimetry, steady state and time resolved fluorometries and diffuse reflectance spectroscopy. The photochemical generation of singlet oxygen (1O2) has been assessed using 9,10-dimethylanthracene as a trap for this reactive oxygen species. It can be concluded that the nature of the polymeric support is of paramount importance for the development of surfaces with bactericidal properties.",

author = "Carles Felip-Le{\'o}n and {Arnau Del Valle}, Carla and Vanesa P{\'e}rez-Laguna and Mill{\'a}n-Lou, {Mar{\'i}a Isabel} and Miravet, {Juan F.} and Maxim Mikhailov and Sokolov, {Maxim N.} and Antonio Rezusta-L{\'o}pez and Francisco Galindo",

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T1 - Superior performance of macroporous over gel type polystyrene as a support for the development of photo-bactericidal materials

AU - Felip-León, Carles

AU - Arnau Del Valle, Carla

AU - Pérez-Laguna, Vanesa

AU - Millán-Lou, María Isabel

AU - Miravet, Juan F.

AU - Mikhailov, Maxim

AU - Sokolov, Maxim N.

AU - Rezusta-López, Antonio

AU - Galindo, Francisco

PY - 2017/7/20

Y1 - 2017/7/20

N2 - A hexanuclear molybdenum cluster [Mo6I8Ac6]2− (1) has been ionically bound onto macroporous (Pmp) and gel-type (Pgel) resins and their performance as materials for the photodynamic inactivation of microorganisms has been studied. It has been found that 1@Pmp in combination with light is able to reduce 99.999999% of the population of Gram-positive Staphylococcus aureus whereas the activity of 1@Pgel is limited to a 99.99% reduction at the same light dose. The same trend is observed with Gram-negative Pseudomonas aeruginosa. A comprehensive study of both materials has been performed using confocal laser scanning microscopy, thermogravimetric analysis, nitrogen porosimetry, steady state and time resolved fluorometries and diffuse reflectance spectroscopy. The photochemical generation of singlet oxygen (1O2) has been assessed using 9,10-dimethylanthracene as a trap for this reactive oxygen species. It can be concluded that the nature of the polymeric support is of paramount importance for the development of surfaces with bactericidal properties.

AB - A hexanuclear molybdenum cluster [Mo6I8Ac6]2− (1) has been ionically bound onto macroporous (Pmp) and gel-type (Pgel) resins and their performance as materials for the photodynamic inactivation of microorganisms has been studied. It has been found that 1@Pmp in combination with light is able to reduce 99.999999% of the population of Gram-positive Staphylococcus aureus whereas the activity of 1@Pgel is limited to a 99.99% reduction at the same light dose. The same trend is observed with Gram-negative Pseudomonas aeruginosa. A comprehensive study of both materials has been performed using confocal laser scanning microscopy, thermogravimetric analysis, nitrogen porosimetry, steady state and time resolved fluorometries and diffuse reflectance spectroscopy. The photochemical generation of singlet oxygen (1O2) has been assessed using 9,10-dimethylanthracene as a trap for this reactive oxygen species. It can be concluded that the nature of the polymeric support is of paramount importance for the development of surfaces with bactericidal properties.

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DO - 10.1039/C7TB01478C

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EP - 6064

JO - Journal of Materials Chemistry B

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SN - 2050-750X

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