Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice

Nicole J W de Wit, Hanneke Bosch-Vermeulen, Els Oosterink, Michael Müller, Roelof van der Meer

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2·3-fold; P 
Original languageEnglish
Pages (from-to)1005-1011
Number of pages7
JournalBritish Journal of Nutrition
Volume105
Issue number7
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Adipose Tissue
  • Animals
  • Bile Acids and Salts
  • Calcium, Dietary
  • Dietary Fats
  • Dietary Supplements
  • Fatty Acids
  • Feces
  • Gene Expression
  • Insulin Resistance
  • Intestinal Absorption
  • Intestine, Small
  • Lipogenesis
  • Lipolysis
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity
  • Trace Elements

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