Supplementation with a low-moderate dose of n-3 long-chain PUFA has no short-term effect on bone resorption in human adults

K M Appleton, WD Fraser, P J Rogers, A R Ness, J H Tobias

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Previous research suggests that n-3 PUFA may play a role in bone health. The present analysis aimed to investigate the impact of n-3 PUFA supplementation on bone resorption in adult men and women. Serum samples from 113 mild-moderately depressed individuals (twenty-six males and eighty-seven females, aged 18-67 years) randomised to receive 1·48 g EPA+DHA/d (n 53) or placebo (n 60) for 12 weeks as part of a large recent randomised controlled trial were assayed for n-3 PUFA status and a bone resorption marker, C-terminal cross-linking telopeptide of type 1 collagen (ß-CTX). Regression analyses revealed that n-3 PUFA status following supplementation was associated with randomisation (placebo/n-3 PUFA) (B = 3·25, 95 % CI 2·60, 3·91, P 
Original languageEnglish
Pages (from-to)1145-1149
Number of pages5
JournalBritish Journal of Nutrition
Issue number8
Publication statusPublished - Apr 2011

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